{"id":"W4402315428","doi":"10.1038/s41573-024-01017-z","title":"Targeting the peripheral neural-tumour microenvironment for cancer therapy","year":2024,"lang":"en","type":"review","venue":"Nature Reviews Drug Discovery","topic":"Cancer, Stress, Anesthesia, and Immune Response","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Cancer Moonshot; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institute of Dental and Craniofacial Research; University of Texas MD Anderson Cancer Center; National Cancer Institute; National Institutes of Health; Vetenskapsrådet; Moonshot Research and Development Program; Knut och Alice Wallenbergs Stiftelse","keywords":"Tumor microenvironment; Cancer; Metastasis; Neuroscience; Immune system; Cancer immunology; Neurogenesis; Cancer cell; Cancer research; Tumour heterogeneity; Medicine; Biology; Immunotherapy; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000671658,0.0009732071,0.001606422,0.001637197,0.0002663773,0.001212334,0.001019504,0.001335708,0.005028796],"category_scores_gemma":[0.0005751196,0.0002702366,0.0005384827,0.001431087,0.0006712199,0.001305627,0.000843612,0.00291684,0.002813448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007725842,"about_ca_system_score_gemma":0.0008699864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001171342,"about_ca_topic_score_gemma":0.003996283,"domain_scores_codex":[0.9998232,0.00003167581,0.00001415882,0.00002653695,0.00007826168,0.00002619536],"domain_scores_gemma":[0.9997631,0.0001040303,0.00003338346,0.000008954721,0.00005857461,0.00003203618],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000116309,0.0001278119,0.0001300392,0.01168772,0.0001164476,0.0001914615,0.00003785702,0.0007044985,0.005069524,0.008394715,0.05856479,0.9148589],"study_design_scores_gemma":[0.00004435148,0.0001053925,0.0004248163,0.001668299,0.00008316951,0.0005603154,0.00002944671,0.0001574392,0.0005738808,0.002849898,0.9934837,0.00001922462],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007819964,0.9982981,0.0001702811,0.0003199487,0.0002751289,0.000005207796,0.00001760748,0.00000991536,0.000825602],"genre_scores_gemma":[0.0007291232,0.9978941,0.0001867475,0.0002353795,0.0001703923,0.000006475501,0.00002501713,0.000001417025,0.0007513218],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005028796,"threshold_uncertainty_score":0.01682293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02894725413478104,"score_gpt":0.3515900694933705,"score_spread":0.3226428153585895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}