{"id":"W4402324581","doi":"10.1007/s00415-024-12670-0","title":"Thrombospondin-4 as potential cerebrospinal fluid biomarker for therapy response in pediatric spinal muscular atrophy","year":2024,"lang":"en","type":"article","venue":"Journal of Neurology","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario","funders":"Deutsche Gesellschaft für Muskelkranke; Bundesministerium für Bildung und Forschung","keywords":"SMA*; Spinal muscular atrophy; Medicine; Cerebrospinal fluid; Biomarker; Atrophy; Pathology; Internal medicine; Oncology; Disease; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004457514,0.0003208778,0.0003913795,0.0004438412,0.0001670843,0.0003409997,0.0002121757,0.0003466143,0.000660483],"category_scores_gemma":[0.001041808,0.0000810656,0.0001717423,0.0003295047,0.0002064691,0.0002000333,0.0001770491,0.0003603011,0.0001108517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003240501,"about_ca_system_score_gemma":0.0002415115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000506834,"about_ca_topic_score_gemma":0.0005989585,"domain_scores_codex":[0.9997506,0.00007284633,0.00003008432,0.00005495967,0.00006769774,0.00002390101],"domain_scores_gemma":[0.9993325,0.0001780113,0.0002939827,0.00002044443,0.0001221953,0.00005274857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003275762,0.0002413129,0.8486341,0.0004298509,0.0002650281,0.001700715,0.0003751263,0.001114621,0.1015568,0.00009478795,0.0005559475,0.04175605],"study_design_scores_gemma":[0.00005977237,0.003281348,0.9377447,0.00009330442,0.0002867096,0.004812637,0.0002986251,0.002613781,0.04853453,0.0001736236,0.002084329,0.0000167905],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963851,0.002619941,0.0004606978,0.00005341097,0.000008933107,0.00001644886,0.0002003132,0.00001723911,0.0002379414],"genre_scores_gemma":[0.9976222,0.0006593322,0.001163827,0.00004537922,0.000009981335,0.00002911814,0.0003176368,0.000003850673,0.0001486299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000660483,"threshold_uncertainty_score":0.002357423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02843078337532318,"score_gpt":0.3532554687248607,"score_spread":0.3248246853495376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}