{"id":"W4402344044","doi":"10.1101/2024.09.05.611453","title":"Human and bats genome robustness under COSMIC mutational signatures","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"National Cancer Institute","keywords":"COSMIC cancer database; Robustness (evolution); Genome; Biology; Evolutionary biology; Computational biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006382467,0.0004013496,0.0003112232,0.0004285077,0.0003438475,0.0004360084,0.0005284421,0.0005134854,0.00112122],"category_scores_gemma":[0.001895905,0.0001740884,0.0006305911,0.0004256052,0.0003614865,0.0004573855,0.0003976109,0.0004899015,0.0002678669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005978944,"about_ca_system_score_gemma":0.0004502488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005082686,"about_ca_topic_score_gemma":0.004622211,"domain_scores_codex":[0.9996085,0.00009201028,0.00002446046,0.0001381654,0.0000954834,0.00004150916],"domain_scores_gemma":[0.9994847,0.0002070913,0.00006945804,0.00009870331,0.0001016053,0.00003838165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0008870842,0.0001545338,0.1054791,0.0005335095,0.0004531189,0.0004835698,0.0005705588,0.6224717,0.2196797,0.0058995,0.004292053,0.03909553],"study_design_scores_gemma":[0.0000488031,0.000716865,0.07082179,0.00003984481,0.0001570927,0.0003894217,0.0002011636,0.8652253,0.05086403,0.004445727,0.00700778,0.00008213831],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816797,0.0003015331,0.01211722,0.0001108832,0.00003426044,0.00003148196,0.002435143,0.001079179,0.002210628],"genre_scores_gemma":[0.9788315,0.0001983178,0.01439794,0.00008557212,0.000007607288,0.00007711005,0.005541143,0.0001904755,0.0006704776],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005082686,"threshold_uncertainty_score":0.01010621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008730293540346433,"score_gpt":0.2310771249743638,"score_spread":0.2223468314340173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}