{"id":"W4402344571","doi":"10.1101/2024.09.07.611787","title":"Molecular glues that inhibit deubiquitylase activity and inflammatory signalling","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Ontario Institute for Cancer Research","funders":"Biotechnology and Biological Sciences Research Council; Wellcome Trust","keywords":"Inflammation; Pharmacology; Chemistry; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002147698,0.0004517845,0.0003036014,0.0003405235,0.0001305722,0.0003198894,0.0002380251,0.000334061,0.002737502],"category_scores_gemma":[0.0001521987,0.0002061854,0.0002558283,0.0001764441,0.0002460249,0.0002152657,0.0002963038,0.0005963186,0.0007893837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003212601,"about_ca_system_score_gemma":0.0001720386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002278864,"about_ca_topic_score_gemma":0.0003211036,"domain_scores_codex":[0.9998606,0.00002188469,0.00001632355,0.00002501785,0.00003922757,0.0000369092],"domain_scores_gemma":[0.9999048,0.00001178238,0.00003648888,0.00001164891,0.000008792252,0.00002651553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002909818,0.0000511961,0.000146708,0.00007028818,0.00002381478,0.00006909948,0.00001083448,0.0003251249,0.9951504,0.0005962331,0.0002663978,0.00299886],"study_design_scores_gemma":[0.00003924565,0.0002017885,0.0004601105,0.000004273493,0.00001141862,0.0001261404,0.000005294571,0.0006094282,0.9947951,0.00007535973,0.003668756,0.000003141483],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9657803,0.006996098,0.01612519,0.0004873383,0.0001762593,0.0001393701,0.001006701,0.0006077107,0.008681062],"genre_scores_gemma":[0.9834406,0.00160936,0.008641752,0.0001628849,0.00001849161,0.00005899458,0.0005699699,0.00006151608,0.005436292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002737502,"threshold_uncertainty_score":0.009157836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0146853826571325,"score_gpt":0.2377949536056948,"score_spread":0.2231095709485623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}