{"id":"W4402354908","doi":"10.1002/advs.202309027","title":"Integrated Electrochemical Aptamer Biosensing and Colorimetric pH Monitoring via Hydrogel Microneedle Assays for Assessing Antibiotic Treatment","year":2024,"lang":"en","type":"article","venue":"Advanced Science","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Waterloo","funders":"","keywords":"Aptamer; FLEX; In vivo; Biosensor; Biomedical engineering; Chromatography; Chemistry; Therapeutic drug monitoring; Antibiotics; Pharmacokinetics; Nanotechnology; Pharmacology; Materials science; Medicine; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005232416,0.0002893883,0.000266584,0.0003713295,0.0004993628,0.0001259977,0.0002243565,0.0001416338,0.00001117401],"category_scores_gemma":[0.0001394808,0.000260602,0.00006991783,0.001395677,0.0007755331,0.0007471953,0.00005865458,0.0004216813,0.00001703101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005545997,"about_ca_system_score_gemma":0.0002185412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008313399,"about_ca_topic_score_gemma":0.000001147818,"domain_scores_codex":[0.997918,0.0000531337,0.0002943194,0.0007558598,0.0002049703,0.0007737675],"domain_scores_gemma":[0.9987305,0.0006921656,0.00006730432,0.0001613644,0.0001310379,0.0002176731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005708433,0.00008951338,0.0005614886,0.00004073614,0.00004567761,0.00002052393,0.0001682084,0.0002640752,0.8139373,0.0001033297,0.000007521633,0.1847045],"study_design_scores_gemma":[0.000742621,0.0001851174,0.0001447602,0.00007629778,0.0001227348,0.00005603128,0.0001706796,0.05522821,0.9371281,0.0003104418,0.00555456,0.000280468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.940918,0.005211139,0.05056581,0.0001233367,0.00194809,0.0005754982,0.00001855118,0.0002110796,0.0004284708],"genre_scores_gemma":[0.975664,0.0006058388,0.02320463,0.0001212524,0.000137503,0.00002203482,0.000009578763,0.00003199797,0.0002031837],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1844241,"threshold_uncertainty_score":0.9999846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08103657302593353,"score_gpt":0.4417352508899187,"score_spread":0.3606986778639851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}