{"id":"W4402357074","doi":"10.1016/j.cell.2024.08.017","title":"Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket","year":2024,"lang":"en","type":"article","venue":"Cell","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Cancer Institute; National Institutes of Health; Lawrence Livermore National Laboratory; Michael Smith Health Research BC; Frederick National Laboratory for Cancer Research; Samuel Waxman Cancer Research Foundation; Laboratory Directed Research and Development; U.S. Department of Energy; Howard Hughes Medical Institute","keywords":"GTPase; Rab; Biology; Guanine nucleotide exchange factor; Allosteric regulation; Guanosine; Cell biology; Guanosine triphosphate; GTP-binding protein regulators; Protein family; Guanosine diphosphate; Ras superfamily; GTPase-activating protein; CDC42; GTP'; G protein; Gene; Genetics; Biochemistry; Signal transduction; Receptor; Nucleotide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001229864,0.00023079,0.0002492126,0.0001843814,0.0001189332,0.0002593515,0.000187089,0.0001413493,0.0003724413],"category_scores_gemma":[0.00008757737,0.00009042393,0.0001526794,0.0001750969,0.0001879192,0.0002233663,0.0002120315,0.0002984455,0.0001908099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002050227,"about_ca_system_score_gemma":0.0001944913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002523748,"about_ca_topic_score_gemma":0.000501766,"domain_scores_codex":[0.9999089,0.00001330364,0.000004982033,0.00002025031,0.00003026464,0.00002218867],"domain_scores_gemma":[0.9999621,0.000007185437,0.0000124551,0.000005294158,0.000004019529,0.000008970078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001396556,0.00002377482,0.0008170167,0.00006031702,0.000006388301,0.0001066232,0.00002351828,0.0006471297,0.9889525,0.0006922602,0.00006996903,0.008460834],"study_design_scores_gemma":[0.00004851179,0.0006138307,0.008336561,0.00001752778,0.0000434805,0.001760773,0.00008616245,0.006641351,0.9684237,0.000594057,0.01341374,0.00002028432],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984619,0.00407143,0.008731458,0.0001042944,0.000008078799,0.00004349957,0.0001739017,0.0001247212,0.002123599],"genre_scores_gemma":[0.9933292,0.001600189,0.004128556,0.00004654538,0.000003894615,0.00001544735,0.0001079974,0.000006591449,0.0007616135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003724413,"threshold_uncertainty_score":0.001487553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009637540649462819,"score_gpt":0.2288433361395504,"score_spread":0.2192057954900876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}