{"id":"W4402357074","doi":"10.1016/j.cell.2024.08.017","title":"Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket","year":2024,"lang":"en","type":"article","venue":"Cell","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Cancer Institute; National Institutes of Health; Lawrence Livermore National Laboratory; Michael Smith Health Research BC; Frederick National Laboratory for Cancer Research; Samuel Waxman Cancer Research Foundation; Laboratory Directed Research and Development; U.S. Department of Energy; Howard Hughes Medical Institute","keywords":"GTPase; Rab; Biology; Guanine nucleotide exchange factor; Allosteric regulation; Guanosine; Cell biology; Guanosine triphosphate; GTP-binding protein regulators; Protein family; Guanosine diphosphate; Ras superfamily; GTPase-activating protein; CDC42; GTP'; G protein; Gene; Genetics; Biochemistry; Signal transduction; Receptor; Nucleotide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001579158,0.0001285579,0.0001008159,0.00003928752,0.00007445701,0.00006289902,0.00006138982,0.00009952076,0.00008408652],"category_scores_gemma":[0.00003413756,0.0001211529,0.00005710088,0.0000701808,0.00005956716,0.000003935771,0.00006598677,0.00007277956,0.00003785433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007237459,"about_ca_system_score_gemma":0.00005352657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001148113,"about_ca_topic_score_gemma":9.214734e-7,"domain_scores_codex":[0.9992427,0.00004727419,0.0001527824,0.0003014793,0.00007540284,0.0001803138],"domain_scores_gemma":[0.9996945,0.00001990833,0.00002893082,0.0001412946,0.00003377348,0.0000816234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001956483,0.00001500083,0.00007562715,0.0001106766,0.00001648146,0.00002383322,0.00002788503,0.00003164355,0.9954154,0.00003269261,0.0030034,0.001227806],"study_design_scores_gemma":[0.000420281,0.00009570409,0.0002100664,0.00006448237,0.00002939222,0.00001705853,0.00006433178,0.003792763,0.9149161,0.0003005292,0.07984424,0.000245059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9507405,0.04162795,0.005664812,0.0001577378,0.0001722967,0.0001889778,0.00001167536,0.00005388463,0.00138222],"genre_scores_gemma":[0.9969559,0.0002626262,0.001031835,0.0004703368,0.0001951207,0.00001489674,0.00009703215,0.00002346288,0.0009487789],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08049929,"threshold_uncertainty_score":0.4940473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009637540649462819,"score_gpt":0.2288433361395504,"score_spread":0.2192057954900876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}