{"id":"W4402357831","doi":"10.1021/acs.jmedchem.4c00490","title":"Structure, Function, and Activity of Small Molecule and Peptide Inhibitors of Protein Arginine Methyltransferase 1","year":2024,"lang":"en","type":"review","venue":"Journal of Medicinal Chemistry","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Canadian Institutes of Health Research; University of Manitoba; Natural Sciences and Engineering Research Council of Canada; CancerCare Manitoba Foundation","keywords":"Chemistry; Arginine; Peptide; Protein arginine methyltransferase 5; Methyltransferase; Function (biology); Small molecule; Biochemistry; Structure–activity relationship; Amino acid; In vitro; Cell biology; Methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003117706,0.0002814934,0.0009300006,0.00008813196,0.00001648597,0.000007255367,0.0001068784,0.0004368887,0.0000149929],"category_scores_gemma":[0.0001172373,0.0002144776,0.0002478265,0.0001421213,0.000180995,0.000004516194,0.00005247723,0.0004985901,6.524842e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003335164,"about_ca_system_score_gemma":0.0004422621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006779581,"about_ca_topic_score_gemma":0.000002800041,"domain_scores_codex":[0.9985925,0.00005733522,0.0007170745,0.0002481824,0.0002647046,0.0001202307],"domain_scores_gemma":[0.9987118,0.00002177809,0.0007713968,0.0001818297,0.0001888297,0.0001243388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002103525,0.00003557718,0.000006703094,0.02620543,0.0007037671,0.0000112652,0.00001896912,0.000005802941,0.8275783,0.000001479488,0.0002635047,0.1449589],"study_design_scores_gemma":[0.001103518,0.0008902369,0.00002592407,0.01749064,0.004085351,0.001181596,0.00004018592,0.000008281733,0.8837428,0.00008836938,0.09098635,0.0003567284],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1583102,0.8410587,0.0002297107,0.00003047899,0.0001133787,0.0001666671,0.00004874328,0.000001847472,0.00004020656],"genre_scores_gemma":[0.09866308,0.9001152,0.000199161,0.000004132324,0.0007732276,0.000004603811,0.00004408894,0.00003966991,0.0001568236],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.1446021,"threshold_uncertainty_score":0.8746141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01229226049537761,"score_gpt":0.2726733932012709,"score_spread":0.2603811327058932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}