{"id":"W4402358038","doi":"10.3390/ph17091186","title":"Dehydroepiandrosterone and Its Metabolite 5-Androstenediol: New Therapeutic Targets and Possibilities for Clinical Application","year":2024,"lang":"en","type":"review","venue":"Pharmaceuticals","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Russian Science Foundation","keywords":"Androstenediol; Dehydroepiandrosterone; Medicine; Hormone; Dehydroepiandrosterone sulfate; Pharmacology; Sarcopenia; Internal medicine; Endocrinology; Androgen","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006574076,0.0004858859,0.001118432,0.00007086349,0.00008186515,0.00008571942,0.0001661514,0.0006764068,0.000004381238],"category_scores_gemma":[0.00009012152,0.0003500947,0.0004114203,0.00009171115,0.0001381202,0.000007458578,0.0002031567,0.0003956904,0.00003060249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001144264,"about_ca_system_score_gemma":0.0001644627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":9.151163e-7,"about_ca_topic_score_gemma":3.474572e-7,"domain_scores_codex":[0.9977015,0.0002255445,0.0006798544,0.0008954313,0.0001100505,0.0003875917],"domain_scores_gemma":[0.9989522,0.0001829867,0.0001542447,0.0002875003,0.00004652911,0.0003765323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007612311,0.00004723933,0.000006091854,0.00777177,0.001117271,0.00000359536,0.00002468568,8.853048e-8,0.001194049,0.0004790554,0.0009607523,0.9883193],"study_design_scores_gemma":[0.0006648466,0.0002425161,0.000001643655,0.0005300176,0.004122115,0.0001294812,0.000004018044,0.0001362752,0.0009228832,0.0003772011,0.992472,0.0003970062],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000272261,0.9966446,0.0003463774,0.0001080412,0.0003624646,0.002015733,0.0001589324,0.00003644868,0.00005516201],"genre_scores_gemma":[0.0005151557,0.9960475,0.0001646311,0.000261569,0.000822016,0.0002874875,0.0003902689,0.00009729454,0.001414108],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9915112,"threshold_uncertainty_score":0.9998951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1144634011344355,"score_gpt":0.4747055223530039,"score_spread":0.3602421212185684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}