{"id":"W4402358038","doi":"10.3390/ph17091186","title":"Dehydroepiandrosterone and Its Metabolite 5-Androstenediol: New Therapeutic Targets and Possibilities for Clinical Application","year":2024,"lang":"en","type":"review","venue":"Pharmaceuticals","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Russian Science Foundation","keywords":"Androstenediol; Dehydroepiandrosterone; Medicine; Hormone; Dehydroepiandrosterone sulfate; Pharmacology; Sarcopenia; Internal medicine; Endocrinology; Androgen","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007582895,0.0004131333,0.0007290311,0.000669022,0.0002148709,0.001363314,0.0004929362,0.001008569,0.006669586],"category_scores_gemma":[0.0003594224,0.0001774479,0.0005480743,0.0004765606,0.0006003172,0.0009721479,0.0004599732,0.00159873,0.001903135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005563476,"about_ca_system_score_gemma":0.000900726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005211222,"about_ca_topic_score_gemma":0.001195365,"domain_scores_codex":[0.9998024,0.00004939157,0.00001473478,0.0000310758,0.00006188601,0.00004053242],"domain_scores_gemma":[0.9998426,0.0000425966,0.00002788212,0.00001077047,0.0000384519,0.0000376061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001447354,0.0006329877,0.001360123,0.006311311,0.0001157315,0.001429775,0.0002583607,0.0007169168,0.06759529,0.02064626,0.02759275,0.8718931],"study_design_scores_gemma":[0.0004066808,0.002365297,0.002881307,0.001292052,0.0001954051,0.003199636,0.0003118463,0.0009627425,0.01663122,0.01141234,0.9602755,0.00006586828],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006621516,0.9765206,0.003125178,0.00485072,0.0006011571,0.00004890279,0.0001199309,0.0000789512,0.008033117],"genre_scores_gemma":[0.08351251,0.8962675,0.0066318,0.002792476,0.001596636,0.0001375204,0.0003762158,0.00003157475,0.008653694],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006669586,"threshold_uncertainty_score":0.02231199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1144634011344355,"score_gpt":0.4747055223530039,"score_spread":0.3602421212185684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}