{"id":"W4402363591","doi":"10.3390/polym16172547","title":"Chitosan siRNA Nanoparticles Produce Significant Non-Toxic Functional Gene Silencing in Kidney Cortices","year":2024,"lang":"en","type":"article","venue":"Polymers","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Polytechnique Montréal","funders":"Polytechnique Montréal","keywords":"Biodistribution; Chitosan; Gene knockdown; In vivo; Hemolysis; Kidney; Toxicity; Chemistry; Pharmacology; Immune system; Biochemistry; Medicine; Biology; In vitro; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001484456,0.000357205,0.0001811289,0.0001849536,0.00008352901,0.0002255815,0.0001405893,0.0002558837,0.0008967504],"category_scores_gemma":[0.0001917133,0.0001516301,0.0002079652,0.00009636284,0.0002072559,0.0001335637,0.0001272194,0.0002466417,0.000199827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002916068,"about_ca_system_score_gemma":0.0002804015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001189657,"about_ca_topic_score_gemma":0.001582335,"domain_scores_codex":[0.9998826,0.00001266266,0.00001214896,0.00003062806,0.00004254796,0.00001939884],"domain_scores_gemma":[0.9998434,0.00003355007,0.00005520574,0.0000137894,0.00003077988,0.00002338236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001739753,0.000002400238,0.0000247092,0.00001535766,0.000002120905,0.0000100698,0.000002528671,0.00001532389,0.999564,0.00001396412,0.000008618672,0.000323503],"study_design_scores_gemma":[0.000002753652,0.0000432214,0.0007527235,0.000001465746,0.000007762047,0.00004693451,0.000002666072,0.0001659216,0.9985529,0.000006480598,0.0004156589,0.000001524712],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786361,0.002370835,0.01474267,0.0001316337,0.00004369103,0.00007505716,0.0004267468,0.0002170828,0.003356142],"genre_scores_gemma":[0.9886551,0.0007322695,0.006584078,0.00006018587,0.000008155329,0.00004610238,0.0003454615,0.00004947385,0.003519187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001189657,"threshold_uncertainty_score":0.002999961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01209994767843956,"score_gpt":0.2378944814913315,"score_spread":0.225794533812892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}