{"id":"W4402363591","doi":"10.3390/polym16172547","title":"Chitosan siRNA Nanoparticles Produce Significant Non-Toxic Functional Gene Silencing in Kidney Cortices","year":2024,"lang":"en","type":"article","venue":"Polymers","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Polytechnique Montréal","funders":"Polytechnique Montréal","keywords":"Biodistribution; Chitosan; Gene knockdown; In vivo; Hemolysis; Kidney; Toxicity; Chemistry; Pharmacology; Immune system; Biochemistry; Medicine; Biology; In vitro; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007356887,0.0001416068,0.0001039046,0.00008127917,0.00004652622,0.00005135225,0.0001245741,0.00007499247,0.00008768913],"category_scores_gemma":[0.00004099596,0.0001298479,0.00007058246,0.0001559132,0.00006096412,0.00001031097,0.00005459469,0.00008694294,0.00004828985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001184856,"about_ca_system_score_gemma":0.0001920852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008492146,"about_ca_topic_score_gemma":0.00002388109,"domain_scores_codex":[0.9989399,0.00002729382,0.0002052872,0.0004251295,0.0001259688,0.0002763776],"domain_scores_gemma":[0.9996315,0.00001003264,0.00003116789,0.0002005363,0.00001420342,0.0001126028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000055539,0.0000381533,0.002849947,0.00003253552,0.00004375242,0.00001834237,0.00013707,0.00007912808,0.9923333,0.00001253307,0.0009375278,0.003462163],"study_design_scores_gemma":[0.0001566174,0.0001529492,0.007952455,0.00006458634,0.00001705177,0.00001226953,0.0001731347,0.0004628338,0.9901648,0.00001130311,0.0006581931,0.0001737799],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953873,0.002445385,0.0001267552,0.0003866199,0.000669566,0.000101544,0.00001979433,0.00002139954,0.0008416287],"genre_scores_gemma":[0.9983828,0.0001918689,0.00004628799,0.0004118899,0.0003804059,0.00002837814,0.00005793491,0.00001955025,0.0004809067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005102508,"threshold_uncertainty_score":0.5295045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01209994767843956,"score_gpt":0.2378944814913315,"score_spread":0.225794533812892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}