{"id":"W4402368962","doi":"10.1210/endocr/bqae116","title":"ZEB1 Inhibits LHβ Subunit Transcription When Overexpressed, but Is Dispensable for LH Synthesis in Mice","year":2024,"lang":"en","type":"article","venue":"Endocrinology","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research","keywords":"Internal medicine; Endocrinology; Protein subunit; Transcription (linguistics); Transcription factor; Biology; Chemistry; Cell biology; Gene; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003912691,0.0007489106,0.0005179308,0.001005171,0.0003054829,0.0005677952,0.000571776,0.0006151267,0.003218608],"category_scores_gemma":[0.0001934251,0.0006887285,0.0006375843,0.0003359641,0.0006871838,0.0003761329,0.0003685127,0.001801993,0.001466564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005365783,"about_ca_system_score_gemma":0.0004350452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00105654,"about_ca_topic_score_gemma":0.001568591,"domain_scores_codex":[0.9994699,0.00006526209,0.0000552156,0.0001354378,0.0001403065,0.0001338599],"domain_scores_gemma":[0.999651,0.00005192148,0.0001135789,0.00004369437,0.00001768242,0.0001222172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002165404,0.0000700911,0.0001604319,0.00003889444,0.00001321709,0.00006200874,0.00001853978,0.00005285579,0.9981013,0.0001861544,0.0001109797,0.0009690133],"study_design_scores_gemma":[0.0001660813,0.0005032618,0.003899163,0.00001761658,0.00004404958,0.0004541541,0.00004926887,0.0009723799,0.9856458,0.0001240304,0.008114732,0.000009467302],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9761835,0.004039634,0.008484981,0.0008815877,0.0001762095,0.0001949671,0.004031967,0.001047898,0.00495939],"genre_scores_gemma":[0.967047,0.003544405,0.005578909,0.0004895927,0.0000537178,0.0004498539,0.003775164,0.0004388116,0.01862245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003218608,"threshold_uncertainty_score":0.01076734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03016019056765571,"score_gpt":0.2748079272776665,"score_spread":0.2446477367100108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}