{"id":"W4402373293","doi":"10.1093/nar/gkae778","title":"Making target sites in large structured RNAs accessible to RNA-cleaving DNAzymes through hybridization with synthetic DNA oligonucleotides","year":2024,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Deoxyribozyme; Oligonucleotide; RNA; Biology; DNA; Purine; Nucleotide; Computational biology; Ribozyme; Cleavage (geology); Biochemistry; Genetics; Molecular biology; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004621344,0.000592031,0.0003528143,0.0001671297,0.000132813,0.0004124826,0.0003534738,0.000524933,0.0007644024],"category_scores_gemma":[0.0004908943,0.000310059,0.0003236496,0.0001342462,0.0004682687,0.0002317898,0.0002601651,0.0007240264,0.0004308724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002986982,"about_ca_system_score_gemma":0.0002389549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002767172,"about_ca_topic_score_gemma":0.0005611575,"domain_scores_codex":[0.9996434,0.00008605178,0.00002807848,0.0001105818,0.00008276545,0.00004893152],"domain_scores_gemma":[0.9996995,0.00009099813,0.0001073655,0.00002925037,0.00003134523,0.00004163358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001299514,0.000007984365,0.00002127359,0.00002296982,0.000001785519,0.00001320395,0.00001112843,0.00007647754,0.9993159,0.00007748597,0.000006075349,0.0004327309],"study_design_scores_gemma":[0.000004128312,0.0001118584,0.00008535226,0.000002027111,0.000004280485,0.00003074068,0.000006736037,0.000245656,0.9988546,0.00002045354,0.0006312687,0.000002810444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9402953,0.001154647,0.05554166,0.0001595731,0.0000911427,0.0001483117,0.0001677921,0.0003541777,0.002087415],"genre_scores_gemma":[0.9372322,0.001157238,0.05782243,0.0001596351,0.00003036039,0.0001921896,0.0002882806,0.00007543636,0.003042197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007644024,"threshold_uncertainty_score":0.002557158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03713442838974998,"score_gpt":0.3762642845566189,"score_spread":0.339129856166869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}