{"id":"W4402374347","doi":"10.1136/jnnp-2024-ehdn.283","title":"I001 Cas9 nickase-mediated contraction of CAG repeats in Huntington’s disease","year":2024,"lang":"en","type":"article","venue":"","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval; Université Laval; University of Guelph","funders":"","keywords":"Contraction (grammar); Genetics; Computer science; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001824518,0.0003264977,0.0003414161,0.000144944,0.0001986184,0.0003105101,0.0002976603,0.0005130732,0.001508588],"category_scores_gemma":[0.000128453,0.0001510964,0.0002422035,0.0001213627,0.0002217498,0.0001854788,0.0002551076,0.0005597363,0.0005141976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003492763,"about_ca_system_score_gemma":0.000179255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000906723,"about_ca_topic_score_gemma":0.001047991,"domain_scores_codex":[0.9998204,0.00002592163,0.0000261822,0.00004850785,0.00005614889,0.0000227886],"domain_scores_gemma":[0.9999385,0.00001040513,0.00001951164,0.00001156297,0.000006569739,0.00001341743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009254949,0.00004197852,0.0001293656,0.00008099253,0.000007624483,0.0001143395,0.00001669508,0.0001344551,0.9951514,0.0002210022,0.000249465,0.003760183],"study_design_scores_gemma":[0.00002583824,0.0003586179,0.001982382,0.00001522909,0.00002139938,0.0009593458,0.00001358557,0.00181847,0.9854385,0.00005867157,0.009298191,0.000009897372],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9436988,0.00811401,0.03367475,0.0004339707,0.0002759369,0.0003389352,0.001386911,0.0009903123,0.01108642],"genre_scores_gemma":[0.9769247,0.002070267,0.01174582,0.00008648783,0.00002168155,0.0001312227,0.001086618,0.0000606319,0.007872547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001508588,"threshold_uncertainty_score":0.005046725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02630828981719514,"score_gpt":0.286438519118499,"score_spread":0.2601302293013039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}