{"id":"W4402377476","doi":"10.21203/rs.3.rs-4803623/v1","title":"Elucidating the enzyme network driving Amaryllidaceae Alkaloids Biosynthesis","year":2024,"lang":"en","type":"preprint","venue":"Research Square","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Université Laval","keywords":"Lycorine; Biosynthesis; Enzyme; Nicotiana benthamiana; Biochemistry; Amaryllidaceae Alkaloids; O-methyltransferase; Chemistry; Alkaloid; Biology; Stereochemistry; Methyltransferase; Methylation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","scholarly_communication","open_science","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.00358682,0.0007110847,0.0007637086,0.0001795696,0.0008744006,0.001330449,0.002291758,0.0009855295,0.00585949],"category_scores_gemma":[0.002277111,0.0005019895,0.000794363,0.0008088202,0.0004954172,0.00006038517,0.008702535,0.006773022,0.0008344363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006260629,"about_ca_system_score_gemma":0.0004502168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003674766,"about_ca_topic_score_gemma":0.00007202414,"domain_scores_codex":[0.9930567,0.0003799855,0.0008303374,0.001623358,0.002161677,0.001947933],"domain_scores_gemma":[0.9924341,0.004312685,0.000188853,0.002312964,0.0003464031,0.0004049605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001490069,0.0005838689,0.006204948,0.0187777,0.002002849,0.0005261704,0.002024009,0.001780647,0.5167947,0.006307223,0.2022955,0.2425534],"study_design_scores_gemma":[0.0002944357,0.00004564739,0.0004390301,0.02052201,0.0002713735,0.0000257916,0.002052878,0.009547015,0.6198993,0.05803432,0.2868049,0.002063345],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.725474,0.03492898,0.000117614,0.01227421,0.001087653,0.001304317,0.000494439,0.001464707,0.2228541],"genre_scores_gemma":[0.9849491,0.00116019,0.0003440084,0.00005572903,0.006108049,0.0004902589,0.0001454034,0.0002435905,0.006503698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2594751,"threshold_uncertainty_score":0.9999436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04123539116732858,"score_gpt":0.3413502369743778,"score_spread":0.3001148458070492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}