{"id":"W4402378820","doi":"10.3390/pharmaceutics16091181","title":"Alternative Strategies for Delivering Immunotherapeutics Targeting the PD-1/PD-L1 Immune Checkpoint in Cancer","year":2024,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke; St. Michael's Hospital","funders":"Canada Research Chairs; Cancer Research Society","keywords":"Immunotherapy; PD-L1; Immune system; Immune checkpoint; Oncolytic virus; Cancer research; Medicine; Cancer immunotherapy; Cancer; T cell; CD8; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004796187,0.0006387749,0.0007182409,0.00186792,0.0002123584,0.0006670232,0.0005867424,0.001001937,0.00258134],"category_scores_gemma":[0.0003853679,0.0002369922,0.0004762323,0.001320999,0.0003134619,0.001240836,0.0004723184,0.001709389,0.001322327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005658616,"about_ca_system_score_gemma":0.0006455776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007458584,"about_ca_topic_score_gemma":0.001778,"domain_scores_codex":[0.999861,0.00002770268,0.00001678112,0.00002454572,0.00005396602,0.00001598435],"domain_scores_gemma":[0.9998676,0.00006476545,0.00002110304,0.000003831008,0.00003350692,0.00000920712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000656658,0.0001134143,0.0000941425,0.02533321,0.00008189858,0.0002523602,0.00008784457,0.0005986379,0.00823927,0.01035338,0.03634631,0.9184339],"study_design_scores_gemma":[0.00001313493,0.0001273815,0.0002847267,0.002106295,0.00005794146,0.0007633999,0.00003423741,0.0001409363,0.001359917,0.001596424,0.9934987,0.00001686973],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001950236,0.9974855,0.0003887573,0.0004483069,0.0003154089,0.000009846103,0.00001792067,0.00001115925,0.001128002],"genre_scores_gemma":[0.0008343702,0.9972287,0.0004028312,0.0003529213,0.0001830116,0.00001379713,0.00002772144,0.000002089118,0.0009546234],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00258134,"threshold_uncertainty_score":0.008635402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1673443496037778,"score_gpt":0.46740316388306,"score_spread":0.3000588142792822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}