{"id":"W4402378820","doi":"10.3390/pharmaceutics16091181","title":"Alternative Strategies for Delivering Immunotherapeutics Targeting the PD-1/PD-L1 Immune Checkpoint in Cancer","year":2024,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke; St. Michael's Hospital","funders":"Canada Research Chairs; Cancer Research Society","keywords":"Immunotherapy; PD-L1; Immune system; Immune checkpoint; Oncolytic virus; Cancer research; Medicine; Cancer immunotherapy; Cancer; T cell; CD8; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009796493,0.000705094,0.001495105,0.0002618539,0.0001517637,0.0001711363,0.0004749826,0.0002698207,0.0001473889],"category_scores_gemma":[0.00002434151,0.000451867,0.001058777,0.0006048378,0.0001948147,0.0001113126,0.0001408726,0.001286294,0.00002321246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009452698,"about_ca_system_score_gemma":0.00112576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006013883,"about_ca_topic_score_gemma":0.00005082638,"domain_scores_codex":[0.9970671,0.0001350182,0.001271685,0.0005387388,0.000339186,0.0006482791],"domain_scores_gemma":[0.9986249,0.0002898427,0.0004633899,0.0004159655,0.0001324202,0.00007349754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006199671,0.0001153804,0.000003560603,0.03088659,0.003396586,0.00004606624,0.001703878,0.00004208758,0.001101016,0.0001647013,0.0002522159,0.961668],"study_design_scores_gemma":[0.001477197,0.0000941211,0.000002477734,0.01593153,0.00386582,0.00005002437,0.0004846628,0.001803066,0.0007453436,0.0001772976,0.9748729,0.0004954927],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001212659,0.9937842,0.0002317267,0.0004236315,0.002053962,0.002736114,0.0002076173,0.00009275578,0.0003487186],"genre_scores_gemma":[0.0006123064,0.996071,0.000232704,0.0005070734,0.0008787822,0.0009446485,0.0001030004,0.0002025881,0.0004479005],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9746208,"threshold_uncertainty_score":0.9997933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1673443496037778,"score_gpt":0.46740316388306,"score_spread":0.3000588142792822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}