{"id":"W4402391375","doi":"10.1016/j.cell.2024.07.023","title":"Safe and effective in vivo delivery of DNA and RNA using proteolipid vehicles","year":2024,"lang":"en","type":"article","venue":"Cell","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University of Alberta","funders":"Nova Scotia Health Research Foundation; Prostate Cancer Canada; Canadian Institutes of Health Research; Alberta Cancer Foundation; Mitacs; Natural Sciences and Engineering Research Council of Canada; Dalhousie Medical Research Foundation","keywords":"Biology; Electroporation; Gene delivery; Immunogenicity; Genetic enhancement; Virology; Gene; Bioinformatics; Computational biology; Immunology; Genetics; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002830126,0.000417387,0.0001938409,0.0002601343,0.000136561,0.0003713222,0.0001884658,0.0004068236,0.0005428588],"category_scores_gemma":[0.0001330398,0.0001335749,0.0002366107,0.0000944709,0.0002903773,0.0002825511,0.0002405449,0.0003858498,0.0002679522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003262497,"about_ca_system_score_gemma":0.0003619425,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002951797,"about_ca_topic_score_gemma":0.0004163119,"domain_scores_codex":[0.9998181,0.00002994789,0.00001340504,0.0000373008,0.00006289509,0.00003831384],"domain_scores_gemma":[0.9999163,0.00001624538,0.00004012775,0.000006936141,0.000009248793,0.00001102072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002845932,0.00001071642,0.00002968465,0.00002456018,0.00000282575,0.00002924864,0.000007703236,0.0001299366,0.9971494,0.0003309218,0.00002819022,0.00222835],"study_design_scores_gemma":[0.000006207809,0.0002105073,0.0001268698,0.000003728671,0.000005117959,0.0001036483,0.000007322068,0.0004145844,0.9968138,0.00006334804,0.002241916,0.000002924943],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8441017,0.005758593,0.1428292,0.0003099959,0.0001121641,0.0003407244,0.0005516804,0.0005857165,0.005410086],"genre_scores_gemma":[0.9542623,0.002485258,0.03736306,0.0001084531,0.00002652775,0.0001733466,0.0004943588,0.00007254854,0.005014189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005428588,"threshold_uncertainty_score":0.002367079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007371168535700206,"score_gpt":0.2306661920893271,"score_spread":0.2232950235536269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}