{"id":"W4402391430","doi":"10.3390/cells13181520","title":"Deciphering the Pathophysiological Mechanisms Underpinning Myoclonus Dystonia Using Pluripotent Stem Cell-Derived Cellular Models","year":2024,"lang":"en","type":"review","venue":"Cells","topic":"Neurological disorders and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Medical Research Council Canada; Cardiff University","keywords":"Dystonia; Neuroscience; Myoclonus; Pathophysiology; Disease; Medicine; Movement disorders; Physical medicine and rehabilitation; Neurological disorder; Underpinning; Psychology; Central nervous system disease; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001737241,0.0008652732,0.001986254,0.00009916392,0.0002507434,0.0001062558,0.0003584668,0.0005548996,0.00006176907],"category_scores_gemma":[0.000004659757,0.0004381359,0.001156203,0.0003502288,0.0001127635,0.00004647351,0.0003907531,0.0009885278,0.0003041043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000215989,"about_ca_system_score_gemma":0.0001829419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001321042,"about_ca_topic_score_gemma":2.671112e-7,"domain_scores_codex":[0.9968643,0.0002563035,0.0007478381,0.001054085,0.0004194678,0.0006580364],"domain_scores_gemma":[0.998548,0.0001536005,0.0002882897,0.0007344871,0.00004445779,0.0002311506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001588587,0.001697085,2.858758e-7,0.05048674,0.002588931,0.01866392,0.0005353777,0.003016319,0.06416487,0.001904754,0.0006803325,0.8561025],"study_design_scores_gemma":[0.006851571,0.006354221,0.000002691422,0.08122858,0.08497977,0.001118349,0.001065531,0.06665643,0.0121567,0.08684464,0.6447351,0.008006433],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001843291,0.989058,0.005819335,0.00004320286,0.000701855,0.001804426,0.00003266191,0.0001852233,0.0005120708],"genre_scores_gemma":[0.004910719,0.9920084,0.001239333,0.0003900683,0.0001556083,0.0001332919,0.00005186107,0.0001646932,0.0009460513],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8480961,"threshold_uncertainty_score":0.9998071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1021319339133462,"score_gpt":0.3064564627360701,"score_spread":0.2043245288227239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}