{"id":"W4402404285","doi":"10.1371/journal.ppat.1012538","title":"The molecular determinants of a universal prion acceptor","year":2024,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Hamster; Biology; Mesocricetus; Virology; Prion protein; Fungal prion; Viral replication; Chinese hamster ovary cell; Cell biology; Genetics; Phenotype; Virus; Molecular biology; Gene; Cell culture; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008609537,0.00008020989,0.00006723279,0.00001964148,0.00006231507,0.00002813074,0.0001609346,0.00005900547,0.00002263884],"category_scores_gemma":[0.00006126519,0.00005932912,0.0001083961,0.00006780263,0.0000459976,0.000002445862,0.00009871659,0.00004108476,0.00001071346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000797125,"about_ca_system_score_gemma":0.00007345599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002260877,"about_ca_topic_score_gemma":0.000003167938,"domain_scores_codex":[0.999421,0.00003962931,0.0001136338,0.0001804084,0.0001019061,0.0001434152],"domain_scores_gemma":[0.9996393,0.00001426718,0.00003064738,0.0002312575,0.00003554351,0.00004903111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002826321,0.00001685283,0.000711561,0.00003828491,0.00004243923,0.00002491106,0.00002455346,0.000004561615,0.9508187,0.0002212178,0.0001390856,0.04792961],"study_design_scores_gemma":[0.000118351,0.0001341996,0.0006527457,0.00005109626,0.00005375571,0.000006818106,0.00006201093,0.0006710968,0.9590586,0.0001296465,0.03893732,0.0001242937],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811286,0.01801495,0.0003258613,0.00005984713,0.000100702,0.0001375302,0.00004730531,0.00001430933,0.000170902],"genre_scores_gemma":[0.9976887,0.001849489,0.0001967783,0.00003072511,0.00007483961,0.00001127047,0.00001297715,0.00001630929,0.0001189024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04780532,"threshold_uncertainty_score":0.2419371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009271461767494209,"score_gpt":0.249749658483083,"score_spread":0.2404781967155888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}