{"id":"W4402404285","doi":"10.1371/journal.ppat.1012538","title":"The molecular determinants of a universal prion acceptor","year":2024,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Hamster; Biology; Mesocricetus; Virology; Prion protein; Fungal prion; Viral replication; Chinese hamster ovary cell; Cell biology; Genetics; Phenotype; Virus; Molecular biology; Gene; Cell culture; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002846484,0.0003500778,0.0002413789,0.0001412185,0.0001790157,0.0004110121,0.0003447225,0.0003964565,0.0005834008],"category_scores_gemma":[0.0002903189,0.0001518606,0.0002209088,0.0000963678,0.0004144714,0.0004507567,0.000410872,0.0005609706,0.0004490463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001761371,"about_ca_system_score_gemma":0.0001934043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001616358,"about_ca_topic_score_gemma":0.0001769477,"domain_scores_codex":[0.9998773,0.00003399961,0.00001258269,0.00002828687,0.00002774033,0.00001990258],"domain_scores_gemma":[0.999785,0.00004450536,0.00007809133,0.00002747479,0.00001963187,0.00004527901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004216589,0.00001596724,0.0007725151,0.00003167647,0.000004485413,0.0001342631,0.00001716155,0.0001200562,0.9970407,0.0005526735,0.00001290335,0.001255306],"study_design_scores_gemma":[0.00002385984,0.0006251045,0.02207188,0.00002629227,0.00004363373,0.002517182,0.00009142669,0.003195164,0.9665273,0.001201941,0.003657921,0.00001816995],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994099,0.0008897733,0.003854838,0.00003540886,0.000006972278,0.00001173647,0.00004690285,0.00002290834,0.001032537],"genre_scores_gemma":[0.9972903,0.0002714208,0.001977188,0.00001894274,0.000004501021,0.000007807864,0.000118891,0.000008796166,0.0003022468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005834008,"threshold_uncertainty_score":0.001951694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009271461767494209,"score_gpt":0.249749658483083,"score_spread":0.2404781967155888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}