{"id":"W4402411114","doi":"10.1038/s44318-024-00200-7","title":"The fitness cost of spurious phosphorylation","year":2024,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; PROTEO; Université du Québec à Montréal","funders":"National Institute of General Medical Sciences; National Human Genome Research Institute; National Institute on Aging; Fonds de recherche du Québec; Fonds de Recherche du Québec - Santé; Danmarks Frie Forskningsfond; National Science Foundation; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institutes of Health; Human Frontier Science Program; European Molecular Biology Organization","keywords":"Biology; Spurious relationship; Saccharomyces cerevisiae; Crosstalk; Phosphorylation; Kinase; Tyrosine; Tyrosine kinase; Receptor tyrosine kinase; Tyrosine phosphorylation; Cell biology; Signal transduction; Phosphoproteomics; Yeast; Biochemistry; Computational biology; Genetics; Protein phosphorylation; Protein kinase A; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005331195,0.00005371762,0.00004406859,0.00001488727,0.0002035634,0.00008996957,0.0002506721,0.00003176018,0.0000332309],"category_scores_gemma":[0.00004861539,0.00002604201,0.00006902862,0.00007586991,0.0001037784,0.000001571299,0.00006977723,0.0001774856,0.00001910213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007844294,"about_ca_system_score_gemma":0.0001028682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003709574,"about_ca_topic_score_gemma":0.000008036749,"domain_scores_codex":[0.9994083,0.00006632001,0.0001274035,0.00007349393,0.0001805539,0.0001439496],"domain_scores_gemma":[0.9996492,0.00003724417,0.00003102375,0.0001581449,0.00008501265,0.00003931995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001618463,0.00002428368,0.0003169047,0.00002257248,0.0001382427,0.00001406084,0.0002146121,0.0007268162,0.880427,0.0008404254,0.02152549,0.09558777],"study_design_scores_gemma":[0.0002418402,0.000243831,0.00176187,0.00004505394,0.00002415231,0.0004328204,0.0001978506,0.001728586,0.6433524,0.002615331,0.3492483,0.0001078856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735914,0.02000579,0.001037015,0.001792278,0.0006224939,0.0001154309,0.00000785566,0.000003900553,0.002823835],"genre_scores_gemma":[0.994563,0.002053839,0.00002433312,0.00003205029,0.0004541715,0.000003913838,0.000003665727,0.000009398596,0.002855656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3277229,"threshold_uncertainty_score":0.1565666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01320214524782651,"score_gpt":0.2937827509215794,"score_spread":0.2805806056737529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}