{"id":"W4402411740","doi":"10.1002/asia.202400817","title":"A DNA Aptamer for 2‐Aminopurine: Binding‐Induced Fluorescence Quenching","year":2024,"lang":"en","type":"article","venue":"Chemistry - An Asian Journal","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Aptamer; Isothermal titration calorimetry; DNA; RNA; Nucleic acid; Systematic evolution of ligands by exponential enrichment; Fluorescence; Molecular biology; Biophysics; Chemistry; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003210224,0.0002422683,0.000183685,0.00005570167,0.0002215678,0.0002364976,0.0002831856,0.0002134591,0.00001677146],"category_scores_gemma":[0.00009445828,0.0002090564,0.000255022,0.0001352608,0.00008432006,0.00001823463,0.00004706821,0.0003173868,0.000003281153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004624744,"about_ca_system_score_gemma":0.000158303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":7.761972e-7,"about_ca_topic_score_gemma":0.000001225582,"domain_scores_codex":[0.9986846,0.00002820214,0.0002989292,0.000462791,0.0001595798,0.0003659257],"domain_scores_gemma":[0.9992452,0.000007182223,0.000106807,0.0003113707,0.000106525,0.0002228806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003342842,0.00003433478,0.00002714282,0.00005825664,0.0000748883,0.00004134637,0.00004720899,5.332944e-7,0.964407,0.000008397692,0.002843699,0.0324238],"study_design_scores_gemma":[0.0001808471,0.0001609187,0.00001643743,0.0001267208,0.00005436785,0.0007475727,0.0002113364,0.0002976597,0.973305,0.000186428,0.02441238,0.0003002923],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916239,0.0003402935,0.005520893,0.000609635,0.0002726318,0.0001257235,0.00004336926,0.0001206287,0.001342905],"genre_scores_gemma":[0.986074,0.00008199115,0.00993856,0.00007521655,0.001897356,0.00001280815,0.0001227227,0.00004383216,0.001753529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03212351,"threshold_uncertainty_score":0.8525073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0139255269935364,"score_gpt":0.297473386651886,"score_spread":0.2835478596583496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}