{"id":"W4402413144","doi":"10.1016/s2213-2600(24)00225-x","title":"Inhaled colistimethate sodium in patients with bronchiectasis and Pseudomonas aeruginosa infection: results of PROMIS-I and PROMIS-II, two randomised, double-blind, placebo-controlled phase 3 trials assessing safety and efficacy over 12 months","year":2024,"lang":"en","type":"article","venue":"The Lancet Respiratory Medicine","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Deutsches Zentrum für Lungenforschung; Grifols; Gallipoli Medical Research Foundation; Metro South Health; Insmed; Gilead Sciences; GlaxoSmithKline; AstraZeneca; University of Dundee; Pfizer","keywords":"Medicine; Placebo; Pseudomonas aeruginosa; Bronchiectasis; Double blind; Internal medicine; Pathology; Alternative medicine; Lung","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005321801,0.0007760918,0.002896755,0.0004415631,0.0002631119,0.0008940043,0.0005760015,0.001739505,0.002624797],"category_scores_gemma":[0.004592643,0.0003515852,0.002519764,0.000543521,0.0007094216,0.0007796907,0.0003545886,0.001629251,0.0003205148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005694627,"about_ca_system_score_gemma":0.0008959933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004969569,"about_ca_topic_score_gemma":0.001130661,"domain_scores_codex":[0.9976501,0.001573238,0.0002860361,0.0001854016,0.0001802745,0.0001249083],"domain_scores_gemma":[0.9970946,0.001319554,0.0008489037,0.0001081471,0.0002205515,0.0004081897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8747001,0.005018345,0.002035421,0.01160928,0.004001515,0.00008617238,0.0001885489,0.0003476303,0.006754882,0.0001774878,0.001260978,0.09381953],"study_design_scores_gemma":[0.8668202,0.120048,0.007383906,0.0005986011,0.001834773,0.00008626191,0.00005402489,0.0001878976,0.0007877773,0.0001157696,0.002058537,0.00002419288],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7882577,0.1980495,0.000807362,0.002352423,0.0008716645,0.005218809,0.001295426,0.00008903145,0.003058038],"genre_scores_gemma":[0.9445554,0.04386523,0.001844387,0.002231922,0.0008195801,0.003555891,0.001277367,0.00002113022,0.001829104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005321801,"threshold_uncertainty_score":0.02814472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06521558791766004,"score_gpt":0.3947745693925531,"score_spread":0.3295589814748931,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}