{"id":"W4402414489","doi":"10.1002/alz.14235","title":"Amygdala atrophies in specific subnuclei in preclinical Alzheimer's disease","year":2024,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture; Canadian Institutes of Health Research; Genentech; National Institutes of Health; Walloon excellence in life sciences and biotechnology; Fondation pour la Recherche sur Alzheimer; H. Lundbeck A/S; Servier; Fondation Saint Luc; Eisai; Fonds De La Recherche Scientifique - FNRS; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; Novartis Pharmaceuticals Corporation; Fondation Louvain; Roche; University of Southern California; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Merck; Alzheimer's Drug Discovery Foundation; IXICO; Takeda Pharmaceutical Company; AbbVie; Alzheimer's Association; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics","keywords":"Amygdala; Neuroscience; Atrophy; Temporal lobe; Hippocampal formation; Neuroimaging; Tauopathy; Psychology; Alzheimer's disease; Dementia; Entorhinal cortex; Basal ganglia; Hippocampus; Magnetic resonance imaging; Medicine; Pathology; Disease; Neurodegeneration; Central nervous system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003271626,0.0002316981,0.0002289402,0.0009623909,0.0002565408,0.0003940428,0.0002122143,0.0002786017,0.001458803],"category_scores_gemma":[0.0005584323,0.0001587081,0.0001755175,0.0003808634,0.0003513942,0.0003011063,0.0003972089,0.0001779174,0.0002424905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002961098,"about_ca_system_score_gemma":0.0001597336,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004667918,"about_ca_topic_score_gemma":0.01186107,"domain_scores_codex":[0.9999162,0.00001495966,0.000006963421,0.00003201417,0.00001797023,0.00001186108],"domain_scores_gemma":[0.9997681,0.00003242986,0.0001196406,0.00002483266,0.00003345359,0.00002157038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00103577,0.00003214583,0.9425974,0.0001044712,0.0001548616,0.0008782324,0.0005270658,0.0004539001,0.03214074,0.0001605894,0.0004626322,0.02145222],"study_design_scores_gemma":[0.000006696313,0.0000413355,0.9966727,0.00001421282,0.00002636868,0.001310616,0.0001160865,0.0003646212,0.0009827194,0.0002322683,0.000229207,0.000003232759],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977922,0.0007651585,0.000401531,0.00003530124,0.000003056745,0.000009587326,0.0001591675,0.00001960857,0.0008143516],"genre_scores_gemma":[0.9991359,0.0001443897,0.0003508248,0.00002020533,0.000002856729,0.000004765587,0.0001249052,0.000004969994,0.0002111591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004667918,"threshold_uncertainty_score":0.009281456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05626633485615491,"score_gpt":0.3582522347780956,"score_spread":0.3019858999219407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}