{"id":"W4402415074","doi":"10.1183/13993003.01551-2024","title":"Cathepsin C (dipeptidyl peptidase 1) inhibition in adults with bronchiectasis: AIRLEAF, a phase II randomised, double-blind, placebo-controlled, dose-finding study","year":2024,"lang":"en","type":"article","venue":"European Respiratory Journal","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Medical Research Council; University of North Carolina at Chapel Hill; Grifols; Imam Abdulrahman Bin Faisal University; Sanofi Genzyme; Deutsches Zentrum für Lungenforschung; Galderma; School of Medicine, New York University; Meiji Seika Pharma; Pfizer; York University; Incyte; Sun Pharma; Dermira; Vertex Pharmaceuticals; MannKind Corporation; Regeneron Pharmaceuticals; Genentech; University of Dundee; LEO Pharma; Gilead Sciences; Ortho Dermatologics; Eli Lilly and Company; AstraZeneca; Chiesi Farmaceutici; CSL Behring; Bundesministerium für Bildung und Forschung; INOVIO Pharmaceuticals; Insmed; Medical Research Council; Teva Pharmaceutical Industries; Sanofi; Deutsche Forschungsgemeinschaft; GlaxoSmithKline; Boehringer Ingelheim; Amgen","keywords":"Medicine; Placebo; Exacerbation; Bronchiectasis; Internal medicine; Gastroenterology; Dipeptidyl peptidase-4; Pharmacology; Lung; Endocrinology; Pathology; Diabetes mellitus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.004947018,0.0005387373,0.0009315975,0.001508311,0.0005385465,0.0004662201,0.0002335257,0.00006946088,0.0003679356],"category_scores_gemma":[0.0005512026,0.000378568,0.0003216269,0.000984012,0.0001925614,0.0006881711,0.0001497948,0.002006916,0.0002389864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005042437,"about_ca_system_score_gemma":0.0006858024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001304734,"about_ca_topic_score_gemma":0.0001038685,"domain_scores_codex":[0.9942524,0.001376398,0.00134976,0.0008058045,0.00135663,0.0008590427],"domain_scores_gemma":[0.9978503,0.0003633143,0.0003139957,0.0005062896,0.0002668596,0.0006992342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9137921,0.003218657,0.0008759099,0.000339854,0.000520095,0.03533174,0.006834962,0.0002920498,0.0166344,0.00001544293,0.002190673,0.01995414],"study_design_scores_gemma":[0.9584274,0.01775262,0.001210313,0.006369674,0.0003517493,0.002559382,0.004071236,0.0004012113,0.001063366,0.000009773865,0.007234313,0.0005489411],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851409,0.004327446,0.0002741107,0.0003089404,0.0002665332,0.004436809,0.00001379761,0.0001834418,0.005048081],"genre_scores_gemma":[0.997207,0.00006777347,0.0003245396,0.0002236667,0.001161323,0.0001845303,0.00001212199,0.0001701038,0.0006489173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04463535,"threshold_uncertainty_score":0.9998666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03791802320327579,"score_gpt":0.3416617243337132,"score_spread":0.3037437011304374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}