{"id":"W4402419491","doi":"10.3390/genes15091189","title":"17α-Ethynylestradiol and Levonorgestrel Exposure of Rainbow Trout RTL-W1 Cells at 18 °C and 21 °C Mainly Reveals Thermal Tolerance, Absence of Estrogenic Effects, and Progestin-Induced Upregulation of Detoxification Genes","year":2024,"lang":"en","type":"article","venue":"Genes","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fundação para a Ciência e a Tecnologia; Centro Interdisciplinar de Investigação Marinha e Ambiental; Wilfrid Laurier University","keywords":"Levonorgestrel; Rainbow trout; Estrogen; Endocrine disruptor; Downregulation and upregulation; Biology; Hormone; Chemistry; Endocrinology; Internal medicine; Cell biology; Endocrine system; Gene; Biochemistry; Fish <Actinopterygii>; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001583696,0.0004074843,0.00042946,0.0002162564,0.0002490071,0.0002742988,0.0002109498,0.0002262839,0.003246229],"category_scores_gemma":[0.00009184584,0.0002337782,0.0005796678,0.0004373065,0.0003076516,0.0001879198,0.0002422901,0.0005255803,0.0008182334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003938588,"about_ca_system_score_gemma":0.0004307449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004726155,"about_ca_topic_score_gemma":0.01072212,"domain_scores_codex":[0.9996995,0.00002515305,0.00003157006,0.0001013206,0.00007554695,0.00006691595],"domain_scores_gemma":[0.9999273,0.00001162926,0.00001549669,0.00001419316,0.00001983035,0.00001156868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001867901,0.0000385646,0.0005979767,0.00004338445,0.000008771605,0.00005267593,0.00005356861,0.00005951475,0.9979401,0.00004007412,0.0001316839,0.0008467649],"study_design_scores_gemma":[0.00003102591,0.00118015,0.03289322,0.00001177141,0.0000419538,0.000247418,0.0001937003,0.0008332933,0.9572617,0.00005622322,0.00722621,0.0000233182],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879488,0.001427117,0.002427815,0.0001935745,0.0001017793,0.00006429176,0.004630981,0.0001391778,0.00306645],"genre_scores_gemma":[0.9572729,0.001887313,0.005789333,0.0002405234,0.00002597915,0.0003661917,0.0107534,0.00006873909,0.0235956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004726155,"threshold_uncertainty_score":0.01085967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009446546830658572,"score_gpt":0.2713684487291091,"score_spread":0.2619219018984505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}