{"id":"W4402419491","doi":"10.3390/genes15091189","title":"17α-Ethynylestradiol and Levonorgestrel Exposure of Rainbow Trout RTL-W1 Cells at 18 °C and 21 °C Mainly Reveals Thermal Tolerance, Absence of Estrogenic Effects, and Progestin-Induced Upregulation of Detoxification Genes","year":2024,"lang":"en","type":"article","venue":"Genes","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fundação para a Ciência e a Tecnologia; Centro Interdisciplinar de Investigação Marinha e Ambiental; Wilfrid Laurier University","keywords":"Levonorgestrel; Rainbow trout; Estrogen; Endocrine disruptor; Downregulation and upregulation; Biology; Hormone; Chemistry; Endocrinology; Internal medicine; Cell biology; Endocrine system; Gene; Biochemistry; Fish <Actinopterygii>; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002228974,0.0001706919,0.0002848762,0.0000375574,0.00005315466,0.00001634663,0.0000934506,0.0000791104,0.00001451448],"category_scores_gemma":[0.00003200871,0.0001387745,0.00004982167,0.0001206435,0.0002769211,0.0001130518,0.00009403899,0.00006003818,0.000001380276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000198668,"about_ca_system_score_gemma":0.00001161996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008471853,"about_ca_topic_score_gemma":0.000007469789,"domain_scores_codex":[0.9988838,0.00007214406,0.0003291965,0.0003581329,0.0001774397,0.0001792183],"domain_scores_gemma":[0.99929,0.0002508875,0.0001721007,0.0001989521,0.00001557374,0.00007246681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002262758,0.00002382559,0.1563554,0.0005436815,0.00001833738,0.000002033657,0.0002566875,0.0001482874,0.8207355,0.00002147209,0.00001709335,0.02185504],"study_design_scores_gemma":[0.000215345,0.0001230484,0.3170987,0.0001451249,0.00003358484,0.00001894858,0.00002705285,0.0006803471,0.6814641,0.00006936672,0.00002328616,0.0001010866],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932429,0.006144905,0.00001627754,0.00003118133,0.00005129104,0.0004042237,0.00001772011,0.00001999956,0.00007156729],"genre_scores_gemma":[0.9971501,0.0006451386,0.002032625,0.000004923696,0.00003122068,0.00001927393,0.000006878616,0.00001680521,0.0000930366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1607433,"threshold_uncertainty_score":0.565906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009446546830658572,"score_gpt":0.2713684487291091,"score_spread":0.2619219018984505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}