{"id":"W4402432829","doi":"10.14785/lymphosign-2024-0008","title":"The outcome of haematopoietic stem cell transplantation in a patient with STAT1 gain-of-function: a case report","year":2024,"lang":"en","type":"article","venue":"LymphoSign Journal","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Stem cell; Haematopoiesis; Transplantation; Gain of function; Function (biology); Outcome (game theory); Oncology; Medicine; Biology; Internal medicine; Cell biology; Genetics; Mathematics; Gene; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003800807,0.0001297597,0.0002652205,0.0001293999,0.0000633271,0.00002372335,0.00004293207,0.00004631079,0.00003735112],"category_scores_gemma":[0.00000781174,0.00007308467,0.00009816707,0.0002462779,0.00005568778,0.00007099129,0.000006430145,0.0001788988,0.000003875075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007717538,"about_ca_system_score_gemma":0.001003357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001165122,"about_ca_topic_score_gemma":0.00004468602,"domain_scores_codex":[0.9984846,0.00006037949,0.0007312921,0.0001501752,0.000391137,0.0001824025],"domain_scores_gemma":[0.9992021,0.0001668674,0.0002453456,0.0002074041,0.00008813218,0.0000901345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.002365227,0.0003735742,0.03715079,0.001542923,0.0004555086,0.914205,0.01339762,0.0004339315,0.001508625,0.0002201879,0.0003410974,0.02800549],"study_design_scores_gemma":[0.005049588,0.001722889,0.002108928,0.001368069,0.0006069881,0.9748957,0.002436354,0.0008795495,0.01021183,0.0001538317,0.0004427143,0.0001235445],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991687,0.002502276,0.004489965,0.0001679567,0.0002730235,0.0003249462,0.00000707687,0.00001491726,0.0005328255],"genre_scores_gemma":[0.9990027,0.00017303,0.0004466716,0.00002625852,0.00003675018,0.00001671589,0.000004556677,0.00002095607,0.0002723885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06069069,"threshold_uncertainty_score":0.2980306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01643700748574568,"score_gpt":0.2623647982676682,"score_spread":0.2459277907819226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}