{"id":"W4402447015","doi":"10.1016/j.tibs.2024.08.004","title":"The expanding landscape of canonical and non-canonical protein phosphorylation","year":2024,"lang":"en","type":"review","venue":"Trends in Biochemical Sciences","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Phosphorylation; Protein phosphorylation; Phosphoprotein; Biology; Kinase; Phosphatase; Phosphorylation cascade; Autophagy-related protein 13; Protein function; Computational biology; Cell biology; Protein kinase A; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000979843,0.001132592,0.00161317,0.001488687,0.0002688655,0.001778902,0.001111375,0.001542264,0.003158617],"category_scores_gemma":[0.0007231037,0.0003073757,0.0004067883,0.002248356,0.001013812,0.002625541,0.001059683,0.002704325,0.002237609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009200479,"about_ca_system_score_gemma":0.001008635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005520878,"about_ca_topic_score_gemma":0.001159405,"domain_scores_codex":[0.9998049,0.0000336984,0.00002185607,0.00003828309,0.00007262193,0.00002869489],"domain_scores_gemma":[0.9997044,0.0001451845,0.00002996357,0.00001342535,0.00006794277,0.00003912636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001746327,0.00005727403,0.0001771434,0.009950614,0.000066252,0.0002307023,0.0000507159,0.0004171808,0.003303292,0.01107981,0.0405597,0.9339326],"study_design_scores_gemma":[0.00002461491,0.00006716892,0.0006701984,0.001319503,0.00006341572,0.0007898881,0.00005698204,0.000182378,0.0007022377,0.005817284,0.9902871,0.00001928287],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009744377,0.9980637,0.0002128528,0.0004623451,0.0003536103,0.000002023303,0.00001252334,0.000008118142,0.0007873482],"genre_scores_gemma":[0.0006018262,0.9980097,0.000197828,0.0002762513,0.0004089742,0.000004239451,0.00002410264,0.000001518873,0.0004755252],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003158617,"threshold_uncertainty_score":0.01056665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03213363828072346,"score_gpt":0.3503440741695733,"score_spread":0.3182104358888498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}