{"id":"W4402453378","doi":"10.20944/preprints202409.0790.v1","title":"Synergistic Dual Targeting of Thioredoxin and Glutathione Systems Irrespective of p53 in Glioblastoma Stem Cells&lt;strong&gt; &lt;/strong&gt;","year":2024,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"bioluminescence and chemiluminescence research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McGill University Health Centre; Cancer Research Society; McGill University","keywords":"Glioblastoma; Thioredoxin; Glutathione; Stem cell; Chemistry; Dual (grammatical number); Cell biology; Cancer research; Biology; Biochemistry; Gene; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001316676,0.0003859048,0.0004214091,0.0002695696,0.0001058325,0.0002533401,0.0002274288,0.000303468,0.0008910567],"category_scores_gemma":[0.00006230124,0.0001415155,0.0002899252,0.0002091292,0.0001986682,0.0002224694,0.0002544051,0.0005088135,0.0001866796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002633573,"about_ca_system_score_gemma":0.0002576846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007806318,"about_ca_topic_score_gemma":0.001706944,"domain_scores_codex":[0.9998817,0.00001642643,0.000009650525,0.00002654501,0.00003281993,0.00003288827],"domain_scores_gemma":[0.9999586,0.00000468653,0.000008943754,0.000005438149,0.000005908316,0.00001630433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006489042,0.0002560157,0.0002678708,0.0001688032,0.00003422029,0.0001266054,0.00004056999,0.0002610377,0.9848555,0.0003461908,0.0004734059,0.01252106],"study_design_scores_gemma":[0.0001675088,0.002671745,0.002268506,0.000009735219,0.00008704381,0.0002968273,0.00003035256,0.001111655,0.9884216,0.00007904739,0.004847283,0.000008779483],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914646,0.002962883,0.00226139,0.0002023955,0.00008281656,0.00009744542,0.0002451846,0.0002047159,0.002478577],"genre_scores_gemma":[0.9959764,0.0009120588,0.001278317,0.00008333001,0.00001009803,0.00007143932,0.0001972964,0.00001167665,0.00145938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008910567,"threshold_uncertainty_score":0.002980888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0362221659161072,"score_gpt":0.306771263288838,"score_spread":0.2705490973727308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}