{"id":"W4402458281","doi":"10.1038/s44321-024-00128-9","title":"Trained immunity of intestinal tuft cells during infancy enhances host defense against enteroviral infections in mice","year":2024,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"Tsinghua University; National Natural Science Foundation of China; Wuhan University; Guangzhou Medical University","keywords":"Tuft; Biology; Immune system; Innate immune system; Immunology; Intracellular; Enterovirus 71; Immunity; Virology; Enterovirus; Cell biology; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000327445,0.0006308793,0.0005106557,0.0006181661,0.0002312362,0.0004964439,0.0003685445,0.0006726854,0.002987002],"category_scores_gemma":[0.0002896661,0.0003167273,0.0006255658,0.0001269175,0.0004713763,0.0004586929,0.0003964962,0.002660412,0.0008184657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003555615,"about_ca_system_score_gemma":0.0002532442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003748412,"about_ca_topic_score_gemma":0.0007614727,"domain_scores_codex":[0.9996026,0.00005430144,0.00003282042,0.0001009814,0.00005724615,0.0001521878],"domain_scores_gemma":[0.9996507,0.00002821642,0.0000747401,0.00004181028,0.00002240444,0.0001821208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002000934,0.0009934463,0.00117657,0.0001462915,0.00001966562,0.0002273647,0.0001634666,0.0001563756,0.9889333,0.0002580417,0.0003121698,0.005612252],"study_design_scores_gemma":[0.000589303,0.01671252,0.03692574,0.0002197244,0.0001973711,0.001036034,0.0005944458,0.002989898,0.9268613,0.0006083343,0.01319547,0.00006984601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926192,0.002025096,0.001577945,0.0003173407,0.000155313,0.0001161809,0.0009556212,0.0002072103,0.002026094],"genre_scores_gemma":[0.9865422,0.001342463,0.001997743,0.0004028227,0.00006629922,0.0003497883,0.001073514,0.00005686643,0.008168197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002987002,"threshold_uncertainty_score":0.00999248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006963536442103877,"score_gpt":0.2558454787783882,"score_spread":0.2488819423362843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}