{"id":"W4402463338","doi":"10.1101/2024.09.09.612141","title":"Antiviral Mechanisms and Preclinical Evaluation of Amantadine Analogs that Continue to Inhibit Influenza A Viruses with M2 <sup>S31N</sup> -Based Drug Resistance","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Rimantadine; Amantadine; Influenza A virus; Adamantane; Virology; Virus; Biology; Chemistry; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005231991,0.0006151552,0.0004881397,0.0002705037,0.0002107725,0.0003448085,0.0004735861,0.00043341,0.001448234],"category_scores_gemma":[0.0002518967,0.0002307513,0.0004686402,0.0001623067,0.000248307,0.0003614114,0.0001451872,0.0009389244,0.0003509749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002805371,"about_ca_system_score_gemma":0.0003059938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000539184,"about_ca_topic_score_gemma":0.0009296174,"domain_scores_codex":[0.9998415,0.00005930629,0.00001619025,0.00001889827,0.00002202216,0.0000420854],"domain_scores_gemma":[0.9998567,0.00002733967,0.00002552559,0.00002149493,0.00002788807,0.00004107447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003586255,0.003338052,0.0006887086,0.0001836569,0.0001033557,0.0001176992,0.00007894119,0.001720186,0.9761165,0.000286549,0.000523063,0.01325696],"study_design_scores_gemma":[0.001875049,0.1360255,0.005683489,0.00003962515,0.000184985,0.0005401972,0.00007621758,0.002773088,0.8453746,0.00017511,0.007225243,0.00002675797],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992819,0.00276563,0.001288219,0.0001211035,0.00005847411,0.0003293273,0.0005167192,0.00006895154,0.002032546],"genre_scores_gemma":[0.9935893,0.001987527,0.001821333,0.00008822225,0.00002934549,0.0002071617,0.0008913758,0.00001375882,0.001371923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001448234,"threshold_uncertainty_score":0.004844844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07901571248186692,"score_gpt":0.3506236926341296,"score_spread":0.2716079801522626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}