{"id":"W4402468447","doi":"10.1101/2024.09.11.24313458","title":"Association between plausible genetic factors and weight loss from GLP1-RA and bariatric surgery: a multi-ancestry study in 10 960 individuals from 9 biobanks","year":2024,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Bariatric Surgery and Outcomes","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Clinical and Translational Science Institute, University of California, Los Angeles; David Geffen School of Medicine, University of California, Los Angeles; National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Eesti Teadusagentuur; Broad Institute; UCLA Health System","keywords":"Biobank; Obesity; Weight loss; Genetic association; Medicine; Psychology; Genetics; Biology; Single-nucleotide polymorphism; Genotype; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001732516,0.00045745,0.0005951287,0.0008864998,0.001150144,0.0008833644,0.0005077682,0.0006958334,0.002043437],"category_scores_gemma":[0.002717889,0.0005826131,0.000800127,0.001625256,0.0004511601,0.0004455417,0.001047638,0.0006912147,0.0002818862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002389425,"about_ca_system_score_gemma":0.0001700743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006321052,"about_ca_topic_score_gemma":0.005847568,"domain_scores_codex":[0.99861,0.000523132,0.0001690538,0.0004818958,0.0001204132,0.00009546219],"domain_scores_gemma":[0.9976754,0.0004576908,0.0009483226,0.0005334839,0.0001498774,0.0002352247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004000909,0.00004829302,0.9962072,0.00002529431,0.0005746224,0.000136488,0.0002536926,0.00006104228,0.0009851062,0.00003376467,0.0001622121,0.001112106],"study_design_scores_gemma":[0.00003288526,0.0001193212,0.9980013,0.00001524032,0.00036521,0.0004211042,0.0002501608,0.0002446844,0.0001501934,0.00004428835,0.0003471717,0.000008427877],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985325,0.0003275779,0.0003327898,0.00002812555,0.000006267966,0.00001048242,0.000616682,0.000004166595,0.0001414691],"genre_scores_gemma":[0.9986981,0.0001104998,0.000368999,0.00004232667,0.000008130075,0.00001707974,0.0005939024,0.000006559894,0.0001544065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006321052,"threshold_uncertainty_score":0.01256847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.053243123582134,"score_gpt":0.2991513382298184,"score_spread":0.2459082146476844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}