{"id":"W4402472398","doi":"10.1200/jco.24.00920","title":"Datopotamab Deruxtecan Versus Chemotherapy in Previously Treated Inoperable/Metastatic Hormone Receptor–Positive Human Epidermal Growth Factor Receptor 2–Negative Breast Cancer: Primary Results From TROPION-Breast01","year":2024,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute; Memorial Sloan-Kettering Cancer Center; AstraZeneca","keywords":"Medicine; Vinorelbine; Internal medicine; Metastatic breast cancer; Oncology; Chemotherapy; Eribulin; Gemcitabine; Breast cancer; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001945692,0.001307938,0.002406295,0.0004412495,0.0002143383,0.0008159928,0.0007072466,0.0008832394,0.003599299],"category_scores_gemma":[0.001061486,0.000443123,0.001759456,0.0003942652,0.0008851683,0.0006125184,0.0003239324,0.002227907,0.0004620421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008892115,"about_ca_system_score_gemma":0.0008146181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001269078,"about_ca_topic_score_gemma":0.004835746,"domain_scores_codex":[0.9993499,0.000428322,0.0000266032,0.00007271444,0.00003891934,0.00008353113],"domain_scores_gemma":[0.9991869,0.0002606521,0.0001877057,0.00005148476,0.00003354826,0.0002796354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9571681,0.008680682,0.001137959,0.0004894191,0.0006733853,0.00003562812,0.00005157608,0.0006206027,0.003976387,0.00007190356,0.0007016002,0.02639272],"study_design_scores_gemma":[0.6926619,0.2966969,0.006015087,0.00006073264,0.0009742727,0.0000866417,0.00004286883,0.0007880835,0.001364567,0.0001560662,0.00113357,0.00001918733],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989844,0.005659616,0.000312479,0.0003805732,0.0002831779,0.001216881,0.0007805016,0.00005623868,0.001466504],"genre_scores_gemma":[0.9912432,0.003506246,0.0006528082,0.0006294794,0.0003007854,0.0009423901,0.0007206562,0.00001719922,0.001987324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003599299,"threshold_uncertainty_score":0.01204079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.120244446036525,"score_gpt":0.4717074371303223,"score_spread":0.3514629910937973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}