{"id":"W4402472398","doi":"10.1200/jco.24.00920","title":"Datopotamab Deruxtecan Versus Chemotherapy in Previously Treated Inoperable/Metastatic Hormone Receptor–Positive Human Epidermal Growth Factor Receptor 2–Negative Breast Cancer: Primary Results From TROPION-Breast01","year":2024,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute; Memorial Sloan-Kettering Cancer Center; AstraZeneca","keywords":"Medicine; Vinorelbine; Internal medicine; Metastatic breast cancer; Oncology; Chemotherapy; Eribulin; Gemcitabine; Breast cancer; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003447244,0.000458929,0.002779278,0.0004907799,0.0000995084,0.00007055651,0.0004898338,0.000576355,0.00172623],"category_scores_gemma":[0.003546054,0.0003438041,0.000601268,0.0008345654,0.0006010535,0.0004156925,0.0001186132,0.003489507,0.00008605754],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00327538,"about_ca_system_score_gemma":0.006595611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004572318,"about_ca_topic_score_gemma":0.0006976965,"domain_scores_codex":[0.9910972,0.002235543,0.004030524,0.0008222608,0.001020965,0.0007935424],"domain_scores_gemma":[0.988343,0.008120082,0.001258838,0.0004163528,0.0009679166,0.0008937893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.1487288,0.004526325,0.02537375,0.0002760834,0.004194617,0.003241979,0.00357423,0.00001517064,0.01197689,0.00005870188,0.0470809,0.7509525],"study_design_scores_gemma":[0.08217158,0.03209367,0.8493729,0.002782907,0.0008426876,0.0004615687,0.0006690708,0.0002183022,0.003230744,0.0003711688,0.02706383,0.0007216081],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9580866,0.002737685,0.00003454462,0.03359118,0.001793345,0.001011775,0.001072242,0.00005683101,0.001615794],"genre_scores_gemma":[0.9779022,0.01308737,0.003263107,0.001617505,0.003223826,0.00005967883,0.0001797784,0.0001178769,0.0005486258],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8239991,"threshold_uncertainty_score":0.9999014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.120244446036525,"score_gpt":0.4717074371303223,"score_spread":0.3514629910937973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}