{"id":"W4402481269","doi":"10.1007/s12195-024-00815-0","title":"Recombinant and Synthetic Affibodies Function Comparably for Modulating Protein Release","year":2024,"lang":"en","type":"article","venue":"Cellular and Molecular Bioengineering","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Chemical, Bioengineering, Environmental, and Transport Systems; Division of Materials Research; National Institute of Dental and Craniofacial Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of General Medical Sciences; Congressionally Directed Medical Research Programs; Natural Sciences and Engineering Research Council of Canada; U.S. Department of Defense; National Institute on Aging; National Institutes of Health; National Science Foundation","keywords":"Recombinant DNA; Self-healing hydrogels; Chemistry; Circular dichroism; Peptide; Affinity chromatography; PEG ratio; Biophysics; Ethylene glycol; Biochemistry; Enzyme; Polymer chemistry; Organic chemistry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001342168,0.0001451867,0.0001864817,0.0001170499,0.0000791503,0.00005964798,0.00002434686,0.00005530506,0.000006711242],"category_scores_gemma":[0.00003502773,0.0001210149,0.00007443569,0.00008378544,0.0000498734,0.00003777618,0.00004024946,0.0001354454,0.000003604045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001518162,"about_ca_system_score_gemma":0.00001971922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001599143,"about_ca_topic_score_gemma":4.564788e-7,"domain_scores_codex":[0.9992229,0.00001156228,0.0001415766,0.0002714024,0.0001195343,0.000233053],"domain_scores_gemma":[0.9996889,0.00003331514,0.0000109364,0.00009934424,0.00003219394,0.0001353322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001187587,0.00002078078,0.0000628294,0.002168085,0.0001068853,0.0001495813,0.0000711545,0.0001098172,0.9709401,0.007208862,0.00004923091,0.01899393],"study_design_scores_gemma":[0.001010839,0.001028529,0.0006066337,0.001995094,0.0002627252,0.0002806659,0.0001121032,0.5187598,0.4256662,0.001354159,0.0484171,0.0005060752],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9223661,0.02055088,0.05545345,0.0006664364,0.0001336898,0.0005187311,0.000006172097,0.00009080421,0.0002137189],"genre_scores_gemma":[0.9963363,0.0001601933,0.002358536,0.00003122634,0.00006800982,0.00005512084,0.00002877618,0.00003153671,0.0009303169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5452739,"threshold_uncertainty_score":0.4934843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01377410344662192,"score_gpt":0.2543842588212447,"score_spread":0.2406101553746228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}