{"id":"W4402481269","doi":"10.1007/s12195-024-00815-0","title":"Recombinant and Synthetic Affibodies Function Comparably for Modulating Protein Release","year":2024,"lang":"en","type":"article","venue":"Cellular and Molecular Bioengineering","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Chemical, Bioengineering, Environmental, and Transport Systems; Division of Materials Research; National Institute of Dental and Craniofacial Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of General Medical Sciences; Congressionally Directed Medical Research Programs; Natural Sciences and Engineering Research Council of Canada; U.S. Department of Defense; National Institute on Aging; National Institutes of Health; National Science Foundation","keywords":"Recombinant DNA; Self-healing hydrogels; Chemistry; Circular dichroism; Peptide; Affinity chromatography; PEG ratio; Biophysics; Ethylene glycol; Biochemistry; Enzyme; Polymer chemistry; Organic chemistry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004818626,0.0006911252,0.0002441411,0.0002075435,0.0001265379,0.0005378521,0.0003188976,0.00058997,0.001626942],"category_scores_gemma":[0.0006860541,0.0001623113,0.0003093787,0.0002230022,0.0004013463,0.0004173775,0.000203336,0.0005022314,0.000558303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002783439,"about_ca_system_score_gemma":0.0001806384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001856094,"about_ca_topic_score_gemma":0.0002022682,"domain_scores_codex":[0.9994473,0.000112741,0.00007722406,0.0001253725,0.0001633641,0.00007403096],"domain_scores_gemma":[0.9995075,0.0001577399,0.0001329401,0.00005969537,0.00007165126,0.00007047573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001224293,0.00002980785,0.0001608559,0.0000647666,0.000009327106,0.00002430319,0.000009448767,0.00008322678,0.9977896,0.00007343624,0.00001658328,0.001616341],"study_design_scores_gemma":[0.00001985909,0.0002375502,0.001049558,0.000007335388,0.00001756931,0.0003780005,0.000009444297,0.0002836894,0.9958729,0.00003333304,0.002087083,0.000003632808],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9564909,0.0105273,0.02734268,0.0002043764,0.000104912,0.0001615702,0.0005664116,0.0001714633,0.004430395],"genre_scores_gemma":[0.9743962,0.002979095,0.01785645,0.0002397623,0.00004644349,0.0001549898,0.001510461,0.00007355786,0.002743021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001626942,"threshold_uncertainty_score":0.005442679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01377410344662192,"score_gpt":0.2543842588212447,"score_spread":0.2406101553746228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}