{"id":"W4402481389","doi":"10.1113/jp285228","title":"Dual role for pannexin 1 at synapses: regulating functional and morphological plasticity","year":2024,"lang":"en","type":"article","venue":"The Journal of Physiology","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Health Canada; Alzheimer Society Research Program; Alzheimer's Society; Fondation Brain Canada; Canadian Bee Research Fund; Canadian Institutes of Health Research; Alzheimer Society; Government of Canada","keywords":"Pannexin; Dendritic spine; Neuroscience; Synapse; Biology; Postsynaptic potential; Synaptic plasticity; Scaffold protein; SPINE (molecular biology); Cell biology; Receptor; Gap junction; Signal transduction; Connexin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002184942,0.0003318527,0.0003842421,0.0003124263,0.0004442226,0.0007999521,0.0003136981,0.0005444953,0.001169604],"category_scores_gemma":[0.0001622646,0.0001133781,0.0002073921,0.0001811488,0.0004816467,0.001359303,0.0006967056,0.0006954959,0.00020435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006174119,"about_ca_system_score_gemma":0.0002331503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002750359,"about_ca_topic_score_gemma":0.0006106342,"domain_scores_codex":[0.9998319,0.00001716423,0.00001439112,0.00004949195,0.00004302692,0.00004400516],"domain_scores_gemma":[0.9998941,0.000008577464,0.00003160799,0.000009963534,0.00001533326,0.00004033381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006647316,0.00000967419,0.0005814298,0.00008143311,0.000006197613,0.000262742,0.0000362562,0.00007575547,0.9939958,0.00122157,0.00006405201,0.003598699],"study_design_scores_gemma":[0.00003623021,0.0002425924,0.05366864,0.00005259283,0.00005824295,0.004063408,0.0003690243,0.002782413,0.9258596,0.003997314,0.008838548,0.00003141902],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9729581,0.01621733,0.005396157,0.001075155,0.00007896502,0.00002304621,0.0001378032,0.00012923,0.00398438],"genre_scores_gemma":[0.9901872,0.004511157,0.002609365,0.0001291101,0.00003029705,0.00001765592,0.00006084585,0.00001644257,0.002437876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001169604,"threshold_uncertainty_score":0.004479706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01585444262818316,"score_gpt":0.2464988462262055,"score_spread":0.2306444035980224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}