{"id":"W4402483255","doi":"10.3389/fnagi.2024.1412735","title":"Association of white matter hyperintensities with cognitive decline and neurodegeneration","year":2024,"lang":"en","type":"article","venue":"Frontiers in Aging Neuroscience","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Canadian Institutes of Health Research; National Institutes of Health; H. Lundbeck A/S; Government of Jiangsu Province; Nanjing Medical University; National Natural Science Foundation of China; Eisai; Servier; China Postdoctoral Science Foundation; Genentech; IXICO; Jiangsu Provincial Department of Human Resources and Social Security; Northern California Institute for Research and Education; BioClinica; Biogen; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association","keywords":"Hyperintensity; Neurodegeneration; Cognitive decline; Association (psychology); White matter; Cognition; Neuroscience; Medicine; Psychology; Internal medicine; Disease; Dementia; Magnetic resonance imaging","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001207596,0.0003505922,0.0002518916,0.0009213252,0.0003049044,0.0005713633,0.0004482791,0.0003475281,0.002326298],"category_scores_gemma":[0.003819458,0.0001935508,0.0005126289,0.0008218694,0.0002682431,0.0003431262,0.0004346987,0.0005445178,0.0002253884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002223286,"about_ca_system_score_gemma":0.0003565802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002982207,"about_ca_topic_score_gemma":0.003874311,"domain_scores_codex":[0.9996549,0.0000872941,0.00004459363,0.0001064638,0.0000565257,0.00005035432],"domain_scores_gemma":[0.9979827,0.0004798505,0.0009473301,0.0002066145,0.0001829831,0.000200455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001905099,0.00002513152,0.9975599,0.00001557983,0.0001774065,0.00005702318,0.00004035298,0.0000655856,0.0001733903,0.00002397236,0.00005220246,0.001618937],"study_design_scores_gemma":[0.000003441979,0.00003539758,0.9992641,0.00000568075,0.00006214365,0.0001403722,0.00003085221,0.0002097658,0.00009307238,0.00007524654,0.00007841778,0.000001506876],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983045,0.0006704999,0.0001711707,0.00005487017,0.000007034321,0.000006908496,0.0003967263,0.000006010098,0.0003822305],"genre_scores_gemma":[0.9992796,0.0001073831,0.000123287,0.00001156527,0.00001175042,0.000007163269,0.000261582,0.000002308613,0.0001953945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002982207,"threshold_uncertainty_score":0.00778228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01114961270660372,"score_gpt":0.2738259888310983,"score_spread":0.2626763761244946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}