{"id":"W4402484216","doi":"10.1158/1078-0432.ccr-24-1098","title":"Update on Recommendations for Cancer Screening and Surveillance in Children with Genomic Instability Disorders","year":2024,"lang":"en","type":"review","venue":"Clinical Cancer Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Institutes of Health; Deutsche Kinderkrebsstiftung; National Cancer Institute; Bundesministerium für Bildung und Forschung; St. Baldrick's Foundation","keywords":"Bloom syndrome; Xeroderma pigmentosum; Genome instability; Nijmegen breakage syndrome; Cancer; Ataxia-telangiectasia; Chromosome instability; Medicine; Fanconi anemia; Genetics; Oncology; DNA repair; Internal medicine; Biology; DNA damage; Chromosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001927227,0.0008531546,0.001484336,0.003127492,0.0003817276,0.001177531,0.001869174,0.003188204,0.01337746],"category_scores_gemma":[0.006447378,0.0004174206,0.001692742,0.00232581,0.0003541854,0.001592231,0.001012119,0.003815094,0.007673815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001773033,"about_ca_system_score_gemma":0.003200861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004985481,"about_ca_topic_score_gemma":0.009462386,"domain_scores_codex":[0.9988574,0.0003336218,0.0002276698,0.00007809644,0.0004297033,0.00007346878],"domain_scores_gemma":[0.9966593,0.001161959,0.0003990162,0.00005639524,0.001515037,0.0002083684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004974439,0.00004920182,0.0001810304,0.01015114,0.00008135699,0.0002144006,0.00006290674,0.0001592443,0.0002599871,0.001793126,0.5117097,0.4752881],"study_design_scores_gemma":[0.00002083345,0.00002179108,0.0004039432,0.007338664,0.00009453418,0.0004350035,0.00002497359,0.00002371711,0.00004051952,0.0005059976,0.9910803,0.000009786369],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000218177,0.9449683,0.0009361642,0.02691955,0.009398829,0.0001738911,0.001138394,0.000168015,0.01607872],"genre_scores_gemma":[0.0007368491,0.970094,0.002744178,0.01503197,0.002171638,0.000181376,0.001634059,0.00002252882,0.007383541],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01337746,"threshold_uncertainty_score":0.04475206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1827902056911555,"score_gpt":0.5230871474230745,"score_spread":0.340296941731919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}