{"id":"W4402489994","doi":"10.1002/em.22626","title":"Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology","year":2024,"lang":"en","type":"article","venue":"Environmental and Molecular Mutagenesis","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"","keywords":"Epigenetics; Biology; Genotoxicity; Genetics; DNA methylation; Computational biology; Workgroup; Histone; Toxicogenomics; Bioinformatics; Gene; Medicine; Gene expression; Computer science; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001806512,0.0006145604,0.000396807,0.001051834,0.0004517486,0.001300466,0.0006925378,0.001211332,0.003613846],"category_scores_gemma":[0.001266479,0.0003288945,0.0004059183,0.0006929434,0.00132461,0.002100751,0.001131236,0.001772947,0.0006707096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00151749,"about_ca_system_score_gemma":0.001370015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004587033,"about_ca_topic_score_gemma":0.01092422,"domain_scores_codex":[0.9996599,0.0000818749,0.00001279071,0.00006422875,0.0001383076,0.0000429418],"domain_scores_gemma":[0.999594,0.0001598657,0.00005463137,0.00003652307,0.0001153757,0.00003971175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0002741626,0.00003705552,0.003289706,0.001745034,0.00008181177,0.000724467,0.001230505,0.002965374,0.7176117,0.04253585,0.005655482,0.2238488],"study_design_scores_gemma":[0.00001569142,0.0003533448,0.01343816,0.0006287872,0.0001519006,0.001685058,0.001333382,0.004277078,0.5704063,0.04057163,0.3670072,0.0001313774],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1654969,0.329557,0.3931716,0.0402864,0.003465523,0.0003822602,0.002162695,0.001129271,0.06434839],"genre_scores_gemma":[0.5697456,0.2153535,0.118512,0.008431357,0.001277477,0.0001946261,0.001497413,0.000369096,0.08461905],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004587033,"threshold_uncertainty_score":0.01208955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01040820680821251,"score_gpt":0.2427893034585769,"score_spread":0.2323810966503644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}