{"id":"W4402490628","doi":"10.1080/21645515.2024.2399915","title":"Syphilis vaccine development: Aligning vaccine design with manufacturing requirements","year":2024,"lang":"en","type":"article","venue":"Human Vaccines & Immunotherapeutics","topic":"Syphilis Diagnosis and Treatment","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Open Philanthropy Project","keywords":"Syphilis; Medicine; Virology; Immunology; Human immunodeficiency virus (HIV)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003894877,0.0006761608,0.0007130285,0.000460544,0.0004260792,0.0002450836,0.0002528022,0.0001628494,0.0009919566],"category_scores_gemma":[0.00000859292,0.0004910863,0.0001725127,0.000372637,0.00001767335,0.0002923274,0.00008768265,0.0003306312,0.0002033249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003817613,"about_ca_system_score_gemma":0.0001781737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003806638,"about_ca_topic_score_gemma":0.00003699614,"domain_scores_codex":[0.997081,0.00006899416,0.0008082574,0.0007868035,0.0005354406,0.0007195334],"domain_scores_gemma":[0.9986015,0.0001614962,0.0001469726,0.0007750354,0.0001382731,0.0001767428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006345117,0.007171574,0.2309765,0.004471516,0.03439992,0.005330403,0.01765817,0.0006671951,0.1269881,0.00376683,0.01424195,0.5479828],"study_design_scores_gemma":[0.01641485,0.003098326,0.2586289,0.00494519,0.002710942,0.001005256,0.0004129414,0.0004355582,0.5534306,0.0006309782,0.1564092,0.001877333],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9647439,0.02464951,0.003946313,0.001745167,0.0004998948,0.002024276,0.000007518444,0.00109166,0.001291757],"genre_scores_gemma":[0.9905328,0.0005903063,0.005099178,0.0009362724,0.0003482115,0.0002194294,0.0001186812,0.0002368319,0.00191829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5461054,"threshold_uncertainty_score":0.9999213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06271040859957382,"score_gpt":0.317222073549503,"score_spread":0.2545116649499292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}