{"id":"W4402490628","doi":"10.1080/21645515.2024.2399915","title":"Syphilis vaccine development: Aligning vaccine design with manufacturing requirements","year":2024,"lang":"en","type":"article","venue":"Human Vaccines & Immunotherapeutics","topic":"Syphilis Diagnosis and Treatment","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Open Philanthropy Project","keywords":"Syphilis; Medicine; Virology; Immunology; Human immunodeficiency virus (HIV)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01347622,0.0009568522,0.001033937,0.001214295,0.0006829769,0.003884471,0.001526722,0.001436276,0.003531205],"category_scores_gemma":[0.01429367,0.000781658,0.0006332014,0.0005492668,0.0009663151,0.002691443,0.001488773,0.002068868,0.00220316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001835469,"about_ca_system_score_gemma":0.006556384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001753217,"about_ca_topic_score_gemma":0.003142663,"domain_scores_codex":[0.9940949,0.002413175,0.0005901717,0.0003710088,0.002159552,0.0003713122],"domain_scores_gemma":[0.9934993,0.002449762,0.001297097,0.00049294,0.001938835,0.0003221173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0007269706,0.00104398,0.009978944,0.005079111,0.0001338232,0.0007655008,0.000783983,0.03809679,0.3729139,0.02529987,0.01353092,0.5316463],"study_design_scores_gemma":[0.0004452546,0.01082475,0.01357392,0.002332106,0.0003863232,0.004008946,0.001820931,0.04411695,0.2956747,0.03632249,0.5902252,0.000268525],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.1876933,0.0598288,0.6465946,0.03797239,0.00205789,0.007014113,0.001571447,0.002280325,0.05498713],"genre_scores_gemma":[0.3449867,0.03638379,0.6034397,0.003889899,0.0008150343,0.002334896,0.001672524,0.0005621825,0.005915282],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.01347622,"threshold_uncertainty_score":0.07126993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06271040859957382,"score_gpt":0.317222073549503,"score_spread":0.2545116649499292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}