{"id":"W4402496557","doi":"10.1038/s41419-024-07003-y","title":"Extracellular vesicle-associated DNA: ten years since its discovery in human blood","year":2024,"lang":"en","type":"review","venue":"Cell Death and Disease","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"McGill University","keywords":"Extracellular vesicles; Liquid biopsy; Extracellular vesicle; Computational biology; DNA; Biomarker; Biology; Isolation (microbiology); Bioinformatics; Microvesicles; Nanotechnology; microRNA; Cell biology; Cancer; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002232183,0.0006171856,0.0007665413,0.0001659442,0.00008284255,0.0001959766,0.0004233658,0.0004367771,0.00001502683],"category_scores_gemma":[0.0001760264,0.000589505,0.0005415879,0.0002286647,0.0001035874,0.00001643132,0.0004006182,0.0003567212,0.00006066615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005827715,"about_ca_system_score_gemma":0.0005557377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007995331,"about_ca_topic_score_gemma":0.000005953258,"domain_scores_codex":[0.9972806,0.0002116401,0.0005942013,0.001130491,0.0002347201,0.0005483229],"domain_scores_gemma":[0.9982928,0.00002518016,0.0002013745,0.0007149331,0.0000303054,0.0007354182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001080119,0.02513547,0.008754989,0.3540351,0.006305086,0.07252959,0.000482943,0.00007282271,0.1280686,0.01678096,0.03584322,0.3509111],"study_design_scores_gemma":[0.002185733,0.0002906478,0.0006418981,0.00985679,0.009772294,0.00003190111,0.00003380284,0.00004153017,0.0007973994,0.000794244,0.97279,0.002763728],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.05547757,0.9427729,0.000006392687,0.000009316762,0.0001460541,0.0006634162,0.0005481445,0.00003766098,0.0003385159],"genre_scores_gemma":[0.05817746,0.9302285,0.00001787248,0.00004196826,0.0002767169,0.0001237687,0.002009468,0.0001512942,0.00897296],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9369468,"threshold_uncertainty_score":0.9996557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01731649553924808,"score_gpt":0.2808162383322117,"score_spread":0.2634997427929636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}