{"id":"W4402503401","doi":"10.1146/annurev-pharmtox-061724-080852","title":"Targeting G Protein–Coupled Receptors in Immuno-Oncological Therapies","year":2024,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Dental and Craniofacial Research; National Cancer Institute","keywords":"G protein-coupled receptor; Immunotherapy; Immune system; Tumor microenvironment; Immune checkpoint; Receptor; Cancer immunotherapy; Cancer; CD8; Blockade; Cancer research; T cell; Computational biology; Biology; Medicine; Bioinformatics; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004660495,0.000646832,0.0008770955,0.00155873,0.0002309729,0.0008243651,0.0006178372,0.001013358,0.005042028],"category_scores_gemma":[0.0003476996,0.0002409875,0.0004692705,0.001231744,0.0003920767,0.001133118,0.0006860498,0.002372991,0.00350839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000533098,"about_ca_system_score_gemma":0.0008017497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005428005,"about_ca_topic_score_gemma":0.001179347,"domain_scores_codex":[0.9998474,0.00002835857,0.00001573448,0.00002383522,0.00006273339,0.00002197668],"domain_scores_gemma":[0.9998558,0.00006106122,0.00001765429,0.000005599593,0.00004086933,0.0000189964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007287395,0.0001128205,0.000127915,0.01082911,0.00006126789,0.0002097442,0.00005392043,0.0004804046,0.004619998,0.009189747,0.0424918,0.9317505],"study_design_scores_gemma":[0.00001278517,0.00008764531,0.0003124272,0.001360049,0.00004158837,0.0006017961,0.00002363437,0.00008634487,0.0004538711,0.001844038,0.9951656,0.00001026189],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001897395,0.9966686,0.0002223436,0.0004317938,0.0004901867,0.000006946228,0.00001888499,0.00001460101,0.001956909],"genre_scores_gemma":[0.0008407457,0.9971244,0.0002185595,0.0002950031,0.0002618151,0.000007470027,0.00002718799,0.00000193259,0.001222932],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005042028,"threshold_uncertainty_score":0.01686722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03210126391893653,"score_gpt":0.3916026465407169,"score_spread":0.3595013826217803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}