{"id":"W4402506611","doi":"10.1038/s41380-024-02736-w","title":"Transcriptomic profiles in major depressive disorder: the role of immunometabolic and cell-cycle-related pathways in depression with different levels of inflammation","year":2024,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; H. Lundbeck A/S; Department of Health and Social Care; National Institute for Health and Care Research; Wellcome Trust; European Federation of Pharmaceutical Industries and Associations; Wellcome; Eli Lilly and Company; National Alliance for Research on Schizophrenia and Depression; NIHR Maudsley Biomedical Research Centre; GlaxoSmithKline; NIHR Cambridge Biomedical Research Centre; European Commission; Pfizer; King's College London","keywords":"Transcriptome; Major depressive disorder; Inflammation; Depression (economics); Internal medicine; C-reactive protein; Biological pathway; Bipolar disorder; Medicine; Bioinformatics; Oncology; Endocrinology; Biology; Gene expression; Gene; Genetics; Lithium (medication)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002160439,0.0001523712,0.0002955099,0.0005503729,0.0002170391,0.0003113354,0.00009985887,0.0001745966,0.001022954],"category_scores_gemma":[0.0003741145,0.00009392387,0.000300054,0.0006927968,0.0001484815,0.000122342,0.0002787654,0.0001935406,0.0001718333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000138452,"about_ca_system_score_gemma":0.0001540998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001111697,"about_ca_topic_score_gemma":0.002001557,"domain_scores_codex":[0.9998354,0.00003400367,0.00001406386,0.00006232363,0.00002367589,0.00003046064],"domain_scores_gemma":[0.9998636,0.000030021,0.00005062197,0.00001450788,0.00002255668,0.00001867391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002967311,0.0001212791,0.5930138,0.0004132532,0.0004306758,0.0003881422,0.0006814375,0.000628806,0.3782779,0.0002355819,0.0006410349,0.02220078],"study_design_scores_gemma":[0.00001660747,0.0001208631,0.9961623,0.00001625188,0.0000791299,0.0002325923,0.0001438105,0.0004021308,0.002130377,0.0001516243,0.0005386108,0.000005604312],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949045,0.0008375322,0.0007918989,0.00005043728,0.000005584216,0.0000215028,0.003074703,0.000007598177,0.000306235],"genre_scores_gemma":[0.9925348,0.0005996863,0.001299418,0.0001133452,0.000009448597,0.0001017703,0.004833792,0.000008976457,0.0004988862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001111697,"threshold_uncertainty_score":0.003422141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004791150039200631,"score_gpt":0.2020578724235261,"score_spread":0.1972667223843254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}