{"id":"W4402509855","doi":"10.1101/2024.09.09.612076","title":"The orphan nuclear receptor NR4A3 is dispensable for resident memory CD8+ T cell generation","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute; Hôpital Maisonneuve-Rosemont","funders":"Canadian Institutes of Health Research","keywords":"Orphan receptor; Neuron-derived orphan receptor 1; Nuclear receptor; CD8; Cytotoxic T cell; Orphan drug; Cell biology; Cancer research; Computational biology; Biology; Genetics; Bioinformatics; Transcription factor; Gene; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001598933,0.0002044436,0.0002710236,0.0001529227,0.0002001167,0.0004070412,0.0003146962,0.0002187957,0.002575931],"category_scores_gemma":[0.0002138427,0.0001855945,0.000307707,0.0001378096,0.0002591091,0.000249604,0.0002505271,0.0004869219,0.0009941439],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002796361,"about_ca_system_score_gemma":0.0003909015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00178216,"about_ca_topic_score_gemma":0.00240621,"domain_scores_codex":[0.999769,0.00004107616,0.00002385572,0.00004968197,0.00006128121,0.00005517163],"domain_scores_gemma":[0.9997543,0.00004746397,0.00007687694,0.00004895785,0.00001818175,0.00005427757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009912614,0.000007951473,0.0002766855,0.00002147006,0.0000033167,0.00007583366,0.000009762643,0.00003376282,0.9986104,0.00007234987,0.00003764719,0.0007517402],"study_design_scores_gemma":[0.000052249,0.0003089892,0.02237169,0.00002709526,0.00003679782,0.001620968,0.000140234,0.002270419,0.9640632,0.0002502818,0.008842266,0.00001577494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907493,0.002178281,0.003344833,0.0001358011,0.00003771996,0.00001722644,0.001207356,0.0001325616,0.002196963],"genre_scores_gemma":[0.9928243,0.0005861776,0.001764693,0.00007566229,0.000009797309,0.00002418379,0.001400559,0.00007119586,0.003243424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002575931,"threshold_uncertainty_score":0.008617342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02671301524115146,"score_gpt":0.2334431597825186,"score_spread":0.2067301445413672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}