{"id":"W4402516799","doi":"10.1080/17460441.2024.2402409","title":"What are the translational challenges associated with Chagas disease drug discovery?","year":2024,"lang":"en","type":"editorial","venue":"Expert Opinion on Drug Discovery","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Universidad de Granada","keywords":"Drug discovery; Chagas disease; Disease; Drug; Computational biology; Medicine; Translational research; Biology; Pharmacology; Bioinformatics; Biotechnology; Virology; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01488752,0.00223398,0.003730545,0.001935523,0.002672496,0.006971797,0.005605742,0.02096574,0.01098131],"category_scores_gemma":[0.04297655,0.0009409515,0.002349907,0.001145142,0.003774083,0.008645453,0.001988494,0.02703718,0.01190839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003774838,"about_ca_system_score_gemma":0.006022471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002165067,"about_ca_topic_score_gemma":0.006455105,"domain_scores_codex":[0.9922575,0.001929776,0.0008376049,0.0006329758,0.003819995,0.0005223069],"domain_scores_gemma":[0.9604591,0.01873815,0.001550719,0.0006472798,0.01401781,0.004586997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002752205,0.000007231438,0.00001227194,0.0004450705,0.00001742008,0.00006248493,0.00001550783,0.000020062,0.00004676991,0.0006353272,0.9887378,0.009972453],"study_design_scores_gemma":[0.00005925555,0.00004365062,0.0001093777,0.0006697046,0.0000518955,0.0001992156,0.00005313012,0.0001072224,0.00006405214,0.003210823,0.9954084,0.00002331401],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.00004007044,0.03480082,0.0001914659,0.1379436,0.8253803,0.00002248241,0.00007411173,0.00007049394,0.001476628],"genre_scores_gemma":[0.0004828865,0.03258026,0.00025007,0.1007947,0.8616524,0.00002612503,0.00006231162,0.00004395956,0.004107333],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.02096574,"threshold_uncertainty_score":0.07873368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03019043566340823,"score_gpt":0.3279637757153308,"score_spread":0.2977733400519225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}