{"id":"W4402522397","doi":"10.1039/d4ra04846f","title":"Cholesterol inhibits oxygen permeation through biological membranes: mechanism against double-bond peroxidation","year":2024,"lang":"en","type":"article","venue":"RSC Advances","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Kasetsart University Research and Development Institute; Alliance de recherche numérique du Canada; Canada Research Chairs; Kasetsart University; Universiteit Utrecht; Technische Universiteit Eindhoven; National Research Council of Thailand","keywords":"Permeation; Chemistry; Membrane; Lipid peroxidation; Mechanism (biology); Oxygen; Biophysics; Double bond; Cholesterol; Biochemistry; Antioxidant; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000364653,0.0004657315,0.0005474662,0.0003660744,0.0002678664,0.0005076119,0.000437758,0.0006236052,0.000955772],"category_scores_gemma":[0.0004411938,0.0001504245,0.0003393941,0.0001742289,0.0005724023,0.0004050512,0.0003730328,0.0006043703,0.0003189152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003367932,"about_ca_system_score_gemma":0.0005042996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007881296,"about_ca_topic_score_gemma":0.0008481612,"domain_scores_codex":[0.9998356,0.00003563269,0.000012508,0.00002042743,0.00004002327,0.0000557787],"domain_scores_gemma":[0.999764,0.00005280628,0.00005200515,0.00003578385,0.00004721271,0.00004822229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002322764,0.00005363461,0.0002889955,0.0002323748,0.00002168674,0.0001502492,0.00003562709,0.00005152091,0.9920684,0.0009767043,0.0001577803,0.005730786],"study_design_scores_gemma":[0.00004946488,0.0002427124,0.001572936,0.00001445395,0.00003136261,0.0002597327,0.00002397611,0.000341122,0.9940515,0.0002202028,0.00318449,0.000008018685],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9543766,0.02145345,0.01399328,0.001750183,0.0004234751,0.0001689105,0.0002620597,0.0002929829,0.007279056],"genre_scores_gemma":[0.9875028,0.006612625,0.002547301,0.0002083718,0.00006057676,0.00004756125,0.0001010283,0.00001618703,0.0029036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000955772,"threshold_uncertainty_score":0.003197312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0199640312324402,"score_gpt":0.2853578257795532,"score_spread":0.265393794547113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}