{"id":"W4402528565","doi":"10.1002/em.22619","title":"Power analyses to inform Duplex Sequencing study designs for <scp>MutaMouse</scp> liver and bone marrow","year":2024,"lang":"en","type":"article","venue":"Environmental and Molecular Mutagenesis","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; Health Canada; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Health Canada; University of Ottawa","keywords":"Bone marrow; Computational biology; Biology; Duplex (building); Genetics; DNA; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001262425,0.0002259617,0.0001743888,0.00007917391,0.0001274829,0.0001010334,0.00007932962,0.00008836044,0.00001627765],"category_scores_gemma":[0.00004012313,0.0002222859,0.00009125543,0.00006228213,0.00006384479,0.000007973572,0.0002242802,0.00004521211,0.00001289876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004864735,"about_ca_system_score_gemma":0.00003188593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002552675,"about_ca_topic_score_gemma":0.00001858389,"domain_scores_codex":[0.9989105,0.00002196498,0.0001859651,0.0004974946,0.0001242684,0.0002597584],"domain_scores_gemma":[0.999527,0.000041787,0.00003007674,0.0002163543,0.000007026717,0.0001777632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001909732,0.00007251744,0.0009163085,0.00003213288,0.0001633751,0.00009273807,0.000486231,0.0001756919,0.9945849,0.00002411067,0.0005656879,0.002867216],"study_design_scores_gemma":[0.00111141,0.002868162,0.01273282,0.00002789304,0.0004333551,0.0001260001,0.003172908,0.0007545936,0.8849508,0.00005362167,0.09330574,0.0004627194],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835625,0.009522392,0.005939715,0.00004584521,0.00007821772,0.0006114846,0.0001366628,0.00001447476,0.00008872624],"genre_scores_gemma":[0.9966621,0.0007240003,0.001239058,0.0005723982,0.00006164372,0.0001133655,0.00008856983,0.00004821282,0.0004906906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1096341,"threshold_uncertainty_score":0.9064558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02062287070202339,"score_gpt":0.2646275824162012,"score_spread":0.2440047117141778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}