{"id":"W4402533735","doi":"10.1038/s41590-024-01952-4","title":"Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption","year":2024,"lang":"en","type":"article","venue":"Nature Immunology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"National Institute of Allergy and Infectious Diseases; U.S. Department of Health and Human Services; National Institutes of Health; National Cancer Institute; Emory University; Gilead Sciences","keywords":"Simian immunodeficiency virus; Blockade; Virology; Immunology; Antiretroviral therapy; Viral load; Human immunodeficiency virus (HIV); Virus; Persistence (discontinuity); Medicine; Immunodeficiency; Immune system; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001770075,0.0002061783,0.000514928,0.0003290416,0.00006374496,0.00001286811,0.0001153859,0.0006201154,0.000299137],"category_scores_gemma":[0.000142884,0.000153797,0.0001998931,0.0001748248,0.0003065069,0.0000558365,0.00007691194,0.0004910406,0.0002606569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001266171,"about_ca_system_score_gemma":0.0001131519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008445983,"about_ca_topic_score_gemma":0.00003869085,"domain_scores_codex":[0.9986597,0.0002033606,0.0003407523,0.0003548207,0.00005499088,0.0003863539],"domain_scores_gemma":[0.999264,0.0003334581,0.00004931042,0.0002540231,0.00006542929,0.00003377704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001817136,0.0003510342,0.001804018,0.00003986123,0.003483407,0.0001441025,0.0006479786,0.000002601064,0.9605204,0.004203632,0.0008011067,0.02618467],"study_design_scores_gemma":[0.01762086,0.02205624,0.03566465,0.0004474726,0.001566737,0.0007480458,0.000689691,0.00009724194,0.7231422,0.0009037842,0.1963226,0.000740459],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9658456,0.03103375,0.00007899393,0.001293435,0.0005916575,0.000352912,0.0002385279,0.00004235341,0.0005226934],"genre_scores_gemma":[0.9966981,0.000151531,0.00004947161,0.00003507767,0.00003472204,0.00003485176,0.0001392449,0.00001537296,0.002841675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2373783,"threshold_uncertainty_score":0.6271658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01176658517271747,"score_gpt":0.3149688228395503,"score_spread":0.3032022376668329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}