{"id":"W4402542669","doi":"10.1002/pd.6656","title":"Response to Wynn and Hokovec Regarding “The Use of cfDNA to Screen for Monogenic Conditions in Low Risk Populations Is Ready for Clinical Use”","year":2024,"lang":"en","type":"letter","venue":"Prenatal Diagnosis","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Wynn; Medicine; Risk assessment; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009985376,0.0004247374,0.0009093537,0.0005994189,0.0001647725,0.0001674356,0.0002716757,0.0007095911,0.00002014769],"category_scores_gemma":[0.03261069,0.0003513594,0.0004855925,0.0004701976,0.0001386989,0.0002134869,0.0003257227,0.001032921,0.00003146789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001256118,"about_ca_system_score_gemma":0.0001402112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001591765,"about_ca_topic_score_gemma":0.0004349093,"domain_scores_codex":[0.9967473,0.0002955571,0.001093,0.0009256165,0.0003848459,0.0005536644],"domain_scores_gemma":[0.9745824,0.02368721,0.0002596573,0.0008906689,0.0002811931,0.0002989218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001496858,0.0001120825,0.057704,0.0003856984,0.000279984,0.00006492516,0.0002314057,0.0001190805,0.000004763765,0.00005472227,0.9372652,0.002281309],"study_design_scores_gemma":[0.002403256,0.001627959,0.1306463,0.004818814,0.002008236,0.00002471647,0.00003762255,0.001667116,0.0004209086,0.0005295529,0.8551708,0.0006447299],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.3160028,0.001049798,0.003839409,0.5921403,0.0009733124,0.008363659,0.07745601,0.0001577452,0.00001695035],"genre_scores_gemma":[0.2042472,0.001815105,0.05848283,0.7025495,0.003398334,0.01220905,0.01216977,0.00056285,0.004565455],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1117556,"threshold_uncertainty_score":0.9998938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2026218380949497,"score_gpt":0.4053005533284164,"score_spread":0.2026787152334667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}