{"id":"W4402542669","doi":"10.1002/pd.6656","title":"Response to Wynn and Hokovec Regarding “The Use of cfDNA to Screen for Monogenic Conditions in Low Risk Populations Is Ready for Clinical Use”","year":2024,"lang":"en","type":"letter","venue":"Prenatal Diagnosis","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Wynn; Medicine; Risk assessment; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002028499,0.0007549907,0.001141227,0.0006283407,0.003173811,0.002113732,0.001433755,0.03144255,0.005505664],"category_scores_gemma":[0.01640283,0.0006262094,0.0009127624,0.0006225316,0.001897602,0.002511356,0.0009527485,0.03213676,0.00508151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002962456,"about_ca_system_score_gemma":0.002448839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005564484,"about_ca_topic_score_gemma":0.007474621,"domain_scores_codex":[0.9984932,0.000448173,0.0001975893,0.0002737339,0.0003652663,0.000221939],"domain_scores_gemma":[0.9954903,0.002381469,0.0003075178,0.0001382178,0.0009904819,0.0006921698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009611304,0.00006593667,0.001357108,0.0000514884,0.0000158966,0.006397495,0.0002349544,0.00008338389,0.0002980237,0.001675335,0.9822159,0.007508385],"study_design_scores_gemma":[0.000163794,0.0002184686,0.004889817,0.0005940201,0.00005905686,0.02108843,0.001561395,0.001126226,0.0007409908,0.009364787,0.9600194,0.0001736975],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0006880737,0.000505878,0.0000845303,0.9883227,0.009035352,0.00001386626,0.00004831803,0.00003404137,0.001267298],"genre_scores_gemma":[0.005451665,0.0007532185,0.0002648013,0.9749563,0.01395477,0.00003723445,0.00004008713,0.00002806176,0.004513912],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.03144255,"threshold_uncertainty_score":0.02149421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2026218380949497,"score_gpt":0.4053005533284164,"score_spread":0.2026787152334667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}