{"id":"W4402544831","doi":"10.21769/bioprotoc.5078","title":"Acutely Modifying Phosphatidylinositol Phosphates on Endolysosomes Using Chemically Inducible Dimerization Systems","year":2024,"lang":"en","type":"article","venue":"BIO-PROTOCOL","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; Ontario Innovation Trust","keywords":"Phosphatidylinositol; Chemistry; Biochemistry; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003183396,0.0005047664,0.0003283751,0.0001689231,0.0002014357,0.0003899212,0.000570395,0.0004643208,0.0007045648],"category_scores_gemma":[0.0001919297,0.0001931796,0.0003172994,0.0002052134,0.0003026743,0.0003669026,0.0004609567,0.0009830226,0.000490367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005772639,"about_ca_system_score_gemma":0.0002384264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006130519,"about_ca_topic_score_gemma":0.0007778336,"domain_scores_codex":[0.9996214,0.00005276925,0.00004515505,0.0001092034,0.0001109165,0.00006047232],"domain_scores_gemma":[0.9998035,0.00003823986,0.00006652305,0.00003274965,0.00002611082,0.00003294245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001846701,0.00001320206,0.00002912915,0.00001740655,0.00000209019,0.00001112289,0.000008202553,0.00005077414,0.9993005,0.00008647522,0.00002077909,0.0004417369],"study_design_scores_gemma":[0.000004081413,0.00003415078,0.0002252067,0.000002008807,0.000003496149,0.00002568381,0.00000643774,0.0007035303,0.9980088,0.00001534831,0.0009680151,0.000003257175],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9519379,0.001117008,0.0428006,0.0002574822,0.00008932671,0.0002344708,0.0008999954,0.0004423505,0.002220935],"genre_scores_gemma":[0.961599,0.001470894,0.03074297,0.0002124167,0.00001726213,0.0002993365,0.001256188,0.0001125238,0.004289384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007045648,"threshold_uncertainty_score":0.004188418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03009127527842825,"score_gpt":0.3095444086148809,"score_spread":0.2794531333364526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}