{"id":"W4402545974","doi":"10.1186/s12934-024-02518-7","title":"Programming Bordetella pertussis lipid A to promote adjuvanticity","year":2024,"lang":"en","type":"article","venue":"Microbial Cell Factories","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Bordetella pertussis; Lipid A; Reactogenicity; Adjuvant; Immune system; Microbiology; Pertussis vaccine; TRIF; Immunization; Biology; Immunology; Toll-like receptor; Innate immune system; Lipopolysaccharide; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001872901,0.0005550359,0.0001420299,0.0002620644,0.00009268282,0.0002890876,0.0002146694,0.0003107672,0.0007382625],"category_scores_gemma":[0.0001765459,0.000113251,0.0002452315,0.0001847248,0.0001899475,0.0002575851,0.0002653426,0.0004881835,0.0002886097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002603922,"about_ca_system_score_gemma":0.0002446206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002883039,"about_ca_topic_score_gemma":0.0003921309,"domain_scores_codex":[0.9998702,0.00002262275,0.0000175127,0.00002314926,0.00003295876,0.00003345952],"domain_scores_gemma":[0.9998186,0.00002738852,0.00008374423,0.00001688961,0.00002637115,0.00002694663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006108559,0.00003606116,0.0001169272,0.00002263165,0.000002372623,0.00001733965,0.0000052394,0.000114599,0.9989354,0.00003609873,0.000009518984,0.0006427313],"study_design_scores_gemma":[0.00001361614,0.0003213574,0.0005541274,0.000004417387,0.000009355881,0.00005612656,0.000007299541,0.0005553402,0.9976478,0.00002975718,0.0007974295,0.000003379646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906244,0.0005162385,0.007716729,0.0001027322,0.00002726699,0.00008366264,0.0002062611,0.00009227171,0.0006304386],"genre_scores_gemma":[0.9856538,0.0005209878,0.01241393,0.00007066641,0.0000105465,0.00006794439,0.0002914149,0.00003463938,0.0009361574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007382625,"threshold_uncertainty_score":0.002469718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01132578356274844,"score_gpt":0.2412332633384243,"score_spread":0.2299074797756759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}