{"id":"W4402546568","doi":"10.1177/17562864241273036","title":"Efficacy and safety of rozanolixizumab in patients with muscle-specific tyrosine kinase autoantibody-positive generalised myasthenia gravis: a subgroup analysis of the randomised, double-blind, placebo-controlled, adaptive phase III MycarinG study","year":2024,"lang":"en","type":"article","venue":"Therapeutic Advances in Neurological Disorders","topic":"Myasthenia Gravis and Thymoma","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"EMD Serono; Schweizerische Multiple Sklerose Gesellschaft; F. Hoffmann-La Roche; Grifols; Fondazione Cariplo; Multiple Sclerosis Society; UCB Pharma; Argenx; Idorsia Pharmaceuticals; Amicus Therapeutics; Janssen Pharmaceuticals; Merck KGaA; Bristol-Myers Squibb; CSL Behring; Pfizer; Biogen; Celgene; H. Lundbeck A/S; Alnylam Pharmaceuticals; Alexion Pharmaceuticals; Regeneron Pharmaceuticals; Novo Nordisk; Teva Pharmaceutical Industries; Sanofi","keywords":"Medicine; Myasthenia gravis; Autoantibody; Placebo; Subgroup analysis; Internal medicine; Tyrosine kinase; Gastroenterology; Antibody; Immunology; Oncology; Pharmacology; Meta-analysis; Receptor; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004435439,0.0004142287,0.001498767,0.000543564,0.00007898943,0.00002335934,0.0002415382,0.0001071004,0.0000388474],"category_scores_gemma":[0.0000290402,0.0002329836,0.0002900789,0.001874866,0.0004522602,0.0001474135,0.00009305683,0.0004660949,3.850568e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003264795,"about_ca_system_score_gemma":0.00003959319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005240164,"about_ca_topic_score_gemma":0.000184511,"domain_scores_codex":[0.9969617,0.0004753543,0.0009424999,0.0007218453,0.0005068549,0.0003917787],"domain_scores_gemma":[0.9984641,0.0006432878,0.0002816684,0.0004447563,0.00008137063,0.00008478866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8896889,0.004825864,0.06220012,0.00004739364,0.001245755,0.00004727149,0.002205263,0.005702529,0.0003228699,0.0009781475,2.84559e-7,0.0327356],"study_design_scores_gemma":[0.537104,0.004790742,0.444657,0.0001434657,0.001753315,0.000001739137,0.0003524503,0.01065258,0.00002994355,0.0002313818,0.00004202505,0.000241358],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876484,0.005928473,0.0006165325,0.0001503535,0.00007181343,0.005385865,0.00003201246,0.00003554343,0.0001309948],"genre_scores_gemma":[0.998872,0.0007105936,0.00004840543,0.0000956515,0.0000141903,0.0001886611,0.000027101,0.00003392442,0.000009422717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3824569,"threshold_uncertainty_score":0.9500794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01523250983793078,"score_gpt":0.2854096034517853,"score_spread":0.2701770936138545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}