{"id":"W4402551704","doi":"10.1158/1538-7445.pancreatic24-c008","title":"Abstract C008: Patient-derived organoids and precision medicine: Insights from the PASS-01 clinical trial in PDAC","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Organoid; Precision medicine; Medicine; Clinical trial; Internal medicine; Computational biology; Oncology; Bioinformatics; Biology; Pathology; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005710676,0.0003550107,0.0005796647,0.0002137544,0.0003313857,0.001355135,0.0004650125,0.0009757575,0.004096506],"category_scores_gemma":[0.002931176,0.0001396393,0.0006437012,0.0003780376,0.0005419057,0.0003991134,0.0007233046,0.001769833,0.0007296939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009420898,"about_ca_system_score_gemma":0.002385846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001485668,"about_ca_topic_score_gemma":0.003020875,"domain_scores_codex":[0.9985858,0.0008336285,0.00007293416,0.00009914479,0.0002843837,0.0001240458],"domain_scores_gemma":[0.9973906,0.0006574502,0.0004418978,0.0003599435,0.0005106796,0.000639464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.1955815,0.0180621,0.06547516,0.004799252,0.002585227,0.002026643,0.001459231,0.01337963,0.1827012,0.005840113,0.08719914,0.4208908],"study_design_scores_gemma":[0.04290452,0.432961,0.1294881,0.001186661,0.002580997,0.00360353,0.001555229,0.008900955,0.1521023,0.003091452,0.2214502,0.0001751256],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9635655,0.006897878,0.002636289,0.003323289,0.0002835714,0.001666263,0.007587283,0.0001760795,0.01386391],"genre_scores_gemma":[0.9684141,0.003806126,0.005070573,0.002310994,0.0001545931,0.0022559,0.01127616,0.00007392697,0.006637666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005710676,"threshold_uncertainty_score":0.03020132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2271617979812408,"score_gpt":0.5427648478731496,"score_spread":0.3156030498919088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}