{"id":"W4402551741","doi":"10.1158/1538-7445.pancreatic24-a010","title":"Abstract A010: A patient first approach using CRISPR-directed gene editing as an augmentative therapy for the treatment of pancreatic ductile adenocarcinoma","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"CRISPR; Genetic enhancement; Genome editing; Medicine; Adenocarcinoma; Pancreatic cancer; Gene; Internal medicine; Cancer; Biology; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005287074,0.0003681195,0.0004492521,0.0003336714,0.0004675259,0.0008991782,0.0003733617,0.0009701359,0.007140389],"category_scores_gemma":[0.0004031344,0.0001693967,0.0007398041,0.0001523829,0.0003976541,0.0004805173,0.0006063117,0.002181684,0.001972891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003198497,"about_ca_system_score_gemma":0.0005509899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004990703,"about_ca_topic_score_gemma":0.0006915356,"domain_scores_codex":[0.9997769,0.00005081177,0.00001638138,0.00005365523,0.00007961395,0.00002265199],"domain_scores_gemma":[0.9998461,0.00002920359,0.00002360729,0.00002139125,0.00002579805,0.00005388011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002380207,0.001750938,0.002937604,0.001014248,0.0002452117,0.005443553,0.0003104,0.001004101,0.5980627,0.009471935,0.05871075,0.3186683],"study_design_scores_gemma":[0.001203349,0.01240188,0.005738633,0.0002669178,0.0004530623,0.03663237,0.0002955889,0.004937196,0.4518111,0.005454991,0.4805894,0.000215513],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5341953,0.03072642,0.272678,0.03792353,0.009500025,0.001538123,0.004934708,0.009522405,0.09898162],"genre_scores_gemma":[0.8014621,0.01374072,0.1006101,0.01598034,0.001003069,0.0007490447,0.002993166,0.0006659277,0.06279556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007140389,"threshold_uncertainty_score":0.02388704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07510771090053593,"score_gpt":0.4341230013169925,"score_spread":0.3590152904164566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}